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hla

General Information
Protegen ID 4178
Sequence Strain (Species/Organism) Staphylococcus aureus
Taxonomy ID 1280
Other Database IDs CDD:273388
Molecule Role Protective antigen
Molecule Role Annotation (Bagnoli et al., 2015)
References
Bagnoli et al., 2015: Bagnoli F, Fontana MR, Soldaini E, Mishra RP, Fiaschi L, Cartocci E, Nardi-Dei V, Ruggiero P, Nosari S, De Falco MG, Lofano G, Marchi S, Galletti B, Mariotti P, Bacconi M, Torre A, Maccari S, Scarselli M, Rinaudo CD, Inoshima N, Savino S, Mori E, Rossi-Paccani S, Baudner B, Pallaoro M, Swennen E, Petracca R, Brettoni C, Liberatori S, Norais N, Monaci E, Bubeck Wardenburg J, Schneewind O, O'Hagan DT, Valiante NM, Bensi G, Bertholet S, De Gregorio E, Rappuoli R, Grandi G. Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112(12); 3680-3685. [PubMed: 25775551].
Gene Information
Gene Name hla
Protein Information
Protein Name hla
NCBI Protein GI AMQ79365
Protein pI 9.19
Protein Weight 34393.79
Protein Length 365
Protein Note beta-channel forming cytolysin; TIGR01002
Protein Sequence
>AMQ79365.1 hla [Staphylococcus aureus]
MKTRIVSSVTTTLLLGSILMNPVANAADSDINIKTGTTDIGSNTTVKTGDLVTYDKENGMHKKVFYSFID
DKNHNKKILVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMS
TLTYGFNGNVTGDDSGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDR
DSWNPVYGNQLFMKTRNGSMKAADNFLDPNKASSLLSSGFSPDFATVITMDRKATKQQTNIDVIYERVRD
DYQLHWTSTNWKGTNTKDKWTDRSSERYKIDWEKEEMTN

Epitope Information
IEDB Linear Epitope