VIOLIN: Vaccine Investigation and Online Information Network

gatA

General Information

Protegen ID

422

Sequence Strain (Species/Organism)

Chlamydophila abortus

VO ID

VO_0010879

Taxonomy ID

218497

Other Database IDs

CDD:234572

Molecule Role

Protective antigen

Molecule Role Annotation

Genetic immunization was used to functionally test the genes of C. abortus as vaccines in a mouse challenge system. Glu-tRNA Gln Amidotransferase (CP #3, gatA) was found to be protective. Three of the clones (CP #1–3) elicited protection that was statistically higher than the unvaccinated control, which has high variance (Stemke-Hale et al., 2005).

Note: Part of CP #3 also belongs to gatB

Related Vaccines(s)

C. abortus DNA vaccine encoding GatA/GatB

References

Stemke-Hale et al., 2005: Stemke-Hale K, Kaltenboeck B, DeGraves FJ, Sykes KF, Huang J, Bu CH, Johnston SA. Screening the whole genome of a pathogen in vivo for individual protective antigens. Vaccine. 2005; 23(23); 3016-3025. [PubMed: 15811648].

Gene Information

Gene Name

gatA

Protein Information

Protein Name

aspartyl/glutamyl-tRNA amidotransferase subunit A

NCBI Protein GI

62184918

Protein pI

6.09

Protein Weight

50155.89

Protein Length

593

Protein Note

aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; PRK00012

Protein Sequence

>YP_219703.1 aspartyl/glutamyl-tRNA amidotransferase subunit A [Chlamydophila abortus S26/3]
MYQKSALELRNAVVSGESSATAIAKYFYNRIKTEDNQIGAFLSLCEERAYEKAAIIDAKVARGEPLGKLA
GVPIGIKDNIHIRGLRTTCASKMLENYIAPFDATVVERIEAEDGVILGKLNMDEFAMGSTTQYSAFHPTK
NPWGLSCVPGGSSGGSAAAVSARFCPIALGSDTGGSIRQPAAFCGVVGFKPSYGAVSRYGLVAFGSSLDQ
IGPLTTVVEDVALAMDVFAGKDDRDATSQKFFTGSFQEALSLDVPSLIGVPMGFLDGLRDDVKENFFASL
SILERQGSRIVEVDLNILDHAVSVYYIVASAEAATNLARFDGIRYGYRSPEAHSIEDIYTISRVQGFGKE
VMRRILLGNYVLSTERQNVYYKKGSAIRAKIIQAFQKAYEKCDVIAMPVCSCPAFADGEILDPTSLYLQD
IYTVAMNLAYLPAIAVPSGFSREGLPLGFQVIGQKGKDQQVCQVGYSFQEHSGIKNLYPKGCNKLVDGEV
K

Epitope Information

IEDB Linear Epitope