VIOLIN: Vaccine Investigation and Online Information Network

MOMP

General Information

Protegen ID

435

VO ID

VO_0010890

Taxonomy ID

83560

Other Database IDs

CDD:279628

Molecule Role

Protective antigen

Molecule Role Annotation

Female BALB/c mice were immunized with chlamydial major outer membrane protein (MOMP) mixed with cholera toxin and CpG oligodeoxynucleotide adjuvants by either the IN or TCI routes. Both intranasal and transcutaneous immunization protected mice against respiratory challenge with Chlamydia (Skelding et al., 2006).

Related Vaccines(s)

C. muridarum MOMP protein vaccine

References

Skelding et al., 2006: Skelding KA, Hickey DK, Horvat JC, Bao S, Roberts KG, Finnie JM, Hansbro PM, Beagley KW. Comparison of intranasal and transcutaneous immunization for induction of protective immunity against Chlamydia muridarum respiratory tract infection. Vaccine. 2006; 24(3); 355-366. [PubMed: 16153755].

Gene Information

Gene Name

MOMP

Protein Information

Protein Name

major outer membrane protein

NCBI Protein GI

1518659

Protein pI

4.86

Protein Weight

39872.84

Protein Length

457

Protein Note

mouse pneumonitis; submitted as Chlamydia trachomatis

Protein Sequence

>AAB07068.1 major outer membrane protein [Chlamydia muridarum]
MKKLLKSVLAFAVLGSASSLHALPVGNPAEPSLMIDGILWEGFGGDPCDPCTTWCDAISLRLGYYGDFVF
DRVLKTDVNKQFEMGAAPTGDADLTTAPTPASRENPAYGKHMQDAEMFTNAAYMALNIWDRFDVFCTLGA
TSGYLKGNSAAFNLVGLFGRDETAVAADDIPNVSLSQAVVELYTDTAFAWSVGARAALWECGCATLGASF
QYAQSKPKVEELNVLCNAAEFTINKPKGYVGQEFPLNIKAGTVSATDTKDASIDYHEWQASLALSYRLNM
FTPYIGVKWSRASFDADTIRIAQPKLETSILKMTTWNPTISGSGIDVDTKITDTLQIVSLQLNKMKSRKS
CGLAIGTTIVDADKYAVTVETRLIDERAAHVNAQFRF

Epitope Information

IEDB Linear Epitope