VIOLIN: Vaccine Investigation and Online Information Network

NH

General Information

Protegen ID

4362

Sequence Strain (Species/Organism)

Leishmania donovani

Taxonomy ID

5661

Other Database IDs

CDD:239117

Molecule Role

Protective antigen

Molecule Role Annotation

(McAtee et al., 2017)

References

McAtee et al., 2017: McAtee CP, Seid CA, Hammond M, Hudspeth E, Keegan BP, Liu Z, Wei J, Zhan B, Arjona-Sabido R, Cruz-Chan V, Dumonteil E, Hotez PJ, Bottazzi ME. Expression, purification, immunogenicity and protective efficacy of a recombinant nucleoside hydrolase from Leishmania donovani, a vaccine candidate for preventing cutaneous leishmaniasis. Protein expression and purification. 2017; 130; 129-136. [PubMed: 27773761].

Gene Information

Gene Name

Protein Information

Protein Name

nucleoside hydrolase

NCBI Protein GI

AAG02281

Protein pI

6.51

Protein Weight

30583.64

Protein Length

375

Protein Note

nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; cd02651

Protein Sequence

>AAG02281.1 nucleoside hydrolase [Leishmania donovani]
MPRKIILDCDPGIDDAVAIFLAHGNPEVELLAITTVVGNQTLEKVTRNARLVADVAGIVGVPVAAGCTKP
LVRGVRNASQIHGETGMGNVSYPPEFKTKLDGRHAVQLIIDLIMSHEPKTITLVPTGGLTNIAMAVRLEP
RIVDRVKEVVLMGGGYHTGNASPVAEFNVFVDPEAAHIVFNESWNVTMVGLDLTHQALATPAVQKRVKEV
GTKPAAFMLQILDFYTKVYEKERNTYATVHDPCAVAYVIDPTVMTTEQVPVDIELNGALTTGMTVADFRY
PRPKHCHTQVAVKLDFDKFWCLVIDALKRIGDPQ

Epitope Information

IEDB Linear Epitope