VIOLIN: Vaccine Investigation and Online Information Network

prohibitin

General Information

Protegen ID

4365

Sequence Strain (Species/Organism)

Leishmania infantum

Taxonomy ID

435258

Other Database IDs

CDD:259799
GOA:A4HX59
InterPro: IPR000163
InterPro: IPR001107
UniProtKB/TrEMBL: A4HX59

Molecule Role

Protective antigen

Molecule Role Annotation

(Dias et al., 2018)

References

Dias et al., 2018: Dias DS, Ribeiro PAF, Martins VT, Lage DP, Ramos FF, Dias ALT, Rodrigues MR, Portela ÁSB, Costa LE, Caligiorne RB, Steiner BT, Chávez-Fumagalli MA, Salles BCS, Santos TTO, Silveira JAG, Magalhães-Soares DF, Roatt BM, Machado-de-Ávila RA, Duarte MC, Menezes-Souza D, Silva ES, Galdino AS, Coelho EAF. Recombinant prohibitin protein of Leishmania infantum acts as a vaccine candidate and diagnostic marker against visceral leishmaniasis. Cellular immunology. 2018; 323; 59-69. [PubMed: 29128045].

Gene Information

Gene Name

prohibitin

NCBI Gene ID

5068054

Protein Information

Protein Name

prohibitin

NCBI Protein GI

XP_001464650

Protein pI

8.28

Protein Weight

28109.152

Protein Length

328

Protein Note

Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; cd03401

Protein Sequence

>XP_001464650.1 prohibitin [Leishmania infantum JPCM5]
MSKLLQKVAIGAMAAGLSVYSCCFVVYPGEACILYNKISGLKDSVYGEGLQGRIIGLDEVLRFNVRVRPR
TLHTMTGTKDLQMVNVRLRVLFRPMADRLPQIYRTFGLDYDERILPSVSNEILKAVVAEYKAEELIQKRD
AVSARIYQLMQEKVNQFGLIIEDLSLVDIQFGADFMTAVEQKQVAQQEAERYRYVVMENEQKRRAAVVRA
EGEAESARLISEAIQKSGSGLLELRRIEAAVEVANQIVPMQNVTFVPKDANMLMSMSR

Epitope Information

IEDB Linear Epitope