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Tc24 (Obselete)

General Information
Protegen ID 4375
Sequence Strain (Species/Organism) Trypanosoma cruzi
Taxonomy ID 5693
Other Database IDs CDD:238008
CDD:290234
Molecule Role Protective antigen
Molecule Role Annotation (Barry et al., 2016)
Related Vaccines(s) T. cruzi Tc24 vaccine
References
Barry et al., 2016: Barry MA, Wang Q, Jones KM, Heffernan MJ, Buhaya MH, Beaumier CM, Keegan BP, Zhan B, Dumonteil E, Bottazzi ME, Hotez PJ. A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease. Human vaccines & immunotherapeutics. 2016; 12(4); 976-987. [PubMed: 26890466].
Gene Information
Gene Name Tc24 (Obselete)
Protein Information
Protein Name Tc24 protein
NCBI Protein GI ABA62611
Protein pI 4.82
Protein Weight 18914.11
Protein Length 239
Protein Note EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; cd00051
Protein Sequence
>ABA62611.1 Tc24 protein, partial (kinetoplast) [Trypanosoma cruzi]
RKEAWERIRQAIPREKTAEAKQRRIELFKKFDKNETGKLCYDEVHSGCLEVLKLDEFTPRVRDITKRAFD
KARALGSKLENKGSEDFVEFLEFRLMLCYIYDFFELTVMFDEIDASGNMLVDEEEFKRAVPKLEAWGAKV
EDPAALFKELDKNGTGSVTFDEFAAWA

Epitope Information
IEDB Linear Epitope