VIOLIN: Vaccine Investigation and Online Information Network

paraflagellar rod protein 3

General Information

Protegen ID

4381

Sequence Strain (Species/Organism)

Trypanosoma cruzi

Taxonomy ID

5693

Other Database IDs

CDD:240364
InterPro: IPR007824
PFAM:PF05149

Molecule Role

Protective antigen

Molecule Role Annotation

(Egui et al., 2012)

Related Vaccines(s)

T. cruzi DNA vaccine encoding PFR2 fused with HSP70

References

Egui et al., 2012: Egui A, Thomas MC, Morell M, Marañón C, Carrilero B, Segovia M, Puerta CJ, Pinazo MJ, Rosas F, Gascón J, López MC. Trypanosoma cruzi paraflagellar rod proteins 2 and 3 contain immunodominant CD8(+) T-cell epitopes that are recognized by cytotoxic T cells from Chagas disease patients. Molecular immunology. 2012; 52(3-4); 289-298. [PubMed: 22750229].

Gene Information

Gene Name

paraflagellar rod protein 3

NCBI Gene ID

3540497

Genbank Accession

AAHK01000953

Chromosome No

Unknown

Gene Starting Position

2712

Gene Ending Position

4481

DNA Sequence

>NW_001849304.1:2712-4481 Trypanosoma cruzi strain CL Brener 1047053516301 genomic scaffold, whole genome shotgun sequence
TATGTCTGCCGAGGAAGCCACTGGGCTGGAGGCTGCCCGCAAGCAGAAGATCCACAACCTGAAGCTGAAG
ACGGCGTGCCTTGAGAATGAGGAACTGATCCAGGAGCTGCACGTCTCGGACTGGTCGGAGACGCAGCGTC
AGAAGCTGCGCGGTGCCCACCTGAAGGCGGAGGAGCTTGTCGCATCCGTCGATGTTGGCACAAAGTGGAA
CCTGACGGAGGCATACGACCTGGCGAAGCTCATGCGTGTGTGCGGCCTTGAAATGAGCCAGCGCGAGCTG
TACCGCCCGGAGGACAAGGCGCAGTTCATGGACATCATTGGTGTGAAGAAGGTGCTGCAGGACCTGAAGC
AGAACCGCAACAAAACACGCGTTGTGAGCTTCACGCAGATGATCGACAACGCCATTGCGAAGATGGAGAA
GGTGGAGGAGGAGCTCCGTCGCTCGCAGCTGGATGCCACACAACTCGCGCAGGTCCCAACCCGGACGCTG
AAGCAGATTGAGGACATCATGAACGCCACACAGATCCAGAACGCACTTGCGTCCACGGACGACCAGATCA
AGACGCAGCTGGCGCAGCTTGAGAAGACAAACGAGATCCAGAACGTTGCCATGCACGACGGTGAGATGCA
GGTCGCGGAGGAGCAGATGTGGACGAAGGTGCAGCTGCAGGAACGGCTGATTGACCTGATTCAGGACAAG
TTCCGGCTGATCACCAAGTGTGAGGAGGAGAACCAACCGTTCAAGAAGATCTATGAGGTTCAGAAGCAGG
CGAACCAGGAGACGAGCCAGATGAAGGATGCAAAGCGGCGCCTGAAGCAGCGGTGTGAGACGGACCTAAA
GCACATTCACGACGCGATCCAGAAGGCAGATCTTGAGGACGCAGAGGCGATGAAGCGACACGCTGCGAAC
AGGGAGAAAAGCGACGGCTTTGTTCGCGAGAACGAGGAGAGGCAGGAAGAGGCATGGAACAAGATTCAGG
ACCTGGAGCGACAGCTGCAGAAGCTGGGTACGGAGCGCTTTGAGGAGGTGAAGCGTCGCATCGAGGAGGT
TGACCGCGAGGAGAAGCGGCGCGTGGAGTACTCGCAGTTCCTTGAGGTCGCGTCACAGCACAAGAAGCTT
CTGGAGCTCACGGTGTACAATTGCGATCTGGCGATACGGTGCACTGGATTGGTGGAGGAATTGGTGTCGG
AGGGCTGTGCCGCAGTGAAGGCCCGTCACGACAAGACAAGCCAAGACCTGGCCGCGCTGCGACTGGAAGT
GCACAAGGAGCACCTGGAGTACTTCCGCATGCTGTACCTCACACTGGGATCTCTCATTTACAAAAAGGAA
AAACGAATGGAGGAAATTGACCGCAATATCCGCACAACGCACATCCAGCTTGAGTTCTGTGTGGAGACAT
TTGACCCGAACGCGAAAAGGCATGCCGACATGAAGAAGGAGCTGTACAAGCTGCGTCAGGGCGTGGAGGA
GGAGCTGGCGATGCTGAAGGAGAAGCAGGCAAAGGCACTGGAGGATTTCAAGGAGTCGGAGGAGGCGCTG
GACGCCGCCGGCATCGAGTTCAACCACCCCGTCGACGAGAACAACGAAGAGGTGTTGACGCGACGCAGCA
AGATGGTGGAGTACCGCTCGCACCTGTCGAAGCAGGAGGAGGTGAAGATTGCCGCGGAGCGCGAGGAGAT
CAAGAGGGCGCGGCTGTTACGCACCGGTGGGGGTGGCAGCGGGGAGCAGCCACGCATTGGGAACAACACC
GCCCCCGCCCGCCTCGAGTG

Protein Information

Protein Name

paraflagellar rod protein 3, putative

NCBI Protein GI

71415533

Protein Accession

XP_809830

Protein pI

5.96

Protein Weight

65585.79

Protein Length

589

Protein Note

in vitro culture

Protein Sequence

>XP_809830.1 paraflagellar rod protein 3, putative [Trypanosoma cruzi]
MSAEEATGLEAARKQKIHNLKLKTACLENEELIQELHVSDWSETQRQKLRGAHLKAEELVASVDVGTKWN
LTEAYDLAKLMRVCGLEMSQRELYRPEDKAQFMDIIGVKKVLQDLKQNRNKTRVVSFTQMIDNAIAKMEK
VEEELRRSQLDATQLAQVPTRTLKQIEDIMNATQIQNALASTDDQIKTQLAQLEKTNEIQNVAMHDGEMQ
VAEEQMWTKVQLQERLIDLIQDKFRLITKCEEENQPFKKIYEVQKQANQETSQMKDAKRRLKQRCETDLK
HIHDAIQKADLEDAEAMKRHAANREKSDGFVRENEERQEEAWNKIQDLERQLQKLGTERFEEVKRRIEEV
DREEKRRVEYSQFLEVASQHKKLLELTVYNCDLAIRCTGLVEELVSEGCAAVKARHDKTSQDLAALRLEV
HKEHLEYFRMLYLTLGSLIYKKEKRMEEIDRNIRTTHIQLEFCVETFDPNAKRHADMKKELYKLRQGVEE
ELAMLKEKQAKALEDFKESEEALDAAGIEFNHPVDENNEEVLTRRSKMVEYRSHLSKQEEVKIAAEREEI
KRARLLRTGGGGSGEQPRIGNNTAPARLE

Epitope Information

IEDB Linear Epitope