VIOLIN: Vaccine Investigation and Online Information Network

gp55

General Information

Protegen ID

444

VO ID

VO_0010899

Taxonomy ID

11096

Other Database IDs

CDD:292945

Molecule Role

Protective antigen

Molecule Role Annotation

Intramuscular vaccination of pigs with immunoaffinity-purified E1 (gp55) in a double water-oil emulsion elicited high titers of neutralizing antibodies between 2 and 4 weeks after vaccination at the lowest dose tested (20 micrograms). The vaccinated pigs were completely protected against intranasal challenge with 100 50% lethal doses of HCV (Classical swine fever virus) strain Brescia (Hulst et al., 1993).

Related Vaccines(s)

Classical swine fever virus E1 protein vaccine

References

Hulst et al., 1993: Hulst MM, Westra DF, Wensvoort G, Moormann RJ. Glycoprotein E1 of hog cholera virus expressed in insect cells protects swine from hog cholera. Journal of virology. 1993; 67(9); 5435-5442. [PubMed: 8350404].

Gene Information

Gene Name

gp55

Protein Information

Protein Name

glycoprotein

NCBI Protein GI

1763691

Protein pI

6.6

Protein Weight

38891.77

Protein Length

452

Protein Note

Pestivirus envelope glycoprotein E2; pfam16329

Protein Sequence

>AAB39835.1 glycoprotein, partial [Classical swine fever virus]
VQGVVWLLLVTGAQGRLACKEDYRYAISSTDEIGLLGAGGLTTTWKEYNHDLQLNDGTVKASCVAGSFKV
TALNVVSRRYLASLHKKALPISVTFELLFDGTNPSTEEMEDDLRSGLCPFDTSPVVKGKYNTTLLNGSAF
YLVCPIGWTGVIECTAVSPTTLRTEVVKTFRRDKPFPHRMDCVTTTVENEDLFYCKLGGNWTCVKGEPVV
YTGGVVKQCRWCGFDFDGPDGLPHYPIGKCILANETGYRIVDSTDCNRDGVVISTEGSHECLIGNTAVKV
HASDERLGPMPCRPKEIVSSAGPVMKTSCTFNYTKTLKNRYYEPRDSYFRQYMLKGEYQYWFDLDATDRH
SDYFAEFVVLVVVALLRGRYVLWLIVTYAVL

Epitope Information

IEDB Linear Epitope