VIOLIN: Vaccine Investigation and Online Information Network

FHc

General Information

Protegen ID

446

VO ID

VO_0010901

Taxonomy ID

32630

Other Database IDs

CDD:285228
CDD:285226

Molecule Role

Protective antigen

Molecule Role Annotation

Purified FHc was used to vaccinate mice and evaluate their survival against challenge with active botulinum neurotoxin serotype F (BoNT/F). Mice that received one injection of 5 microg or two injections of >or=0.04 microg of FHc were completely protected (Yu et al., 2008).

Related Vaccines(s)

C. botulinum FHc protein vaccine

References

Yu et al., 2008: Yu YZ, Li N, Wang RL, Zhu HQ, Wang S, Yu WY, Sun ZW. Evaluation of a recombinant Hc of Clostridium botulinum neurotoxin serotype F as an effective subunit vaccine. Clinical and vaccine immunology : CVI. 2008; 15(12); 1819-1823. [PubMed: 18845829].

Gene Information

Gene Name

FHc

Protein Information

Protein Name

recombinant botulinum toxin F Hc domain

NCBI Protein GI

166236883

Protein pI

9.28

Protein Weight

47714.27

Protein Length

504

Protein Note

Clostridium neurotoxin, N-terminal receptor binding; pfam07953

Protein Sequence

>ABY86211.1 recombinant botulinum toxin F Hc domain [synthetic construct]
MYFNKLYKKIKDNSILDMRYENNKFIDISGYGSNISINGDVYIYSTNRNQFGIYSSKPSEVNIAQNNDII
YNGRYQNFSISFWVRIPKYFNKVNLNNEYTIIDCIRNNNSGWKISLNYNKIIWTLQDTAGNNQKLVFNYT
QMISISDYINKWIFVTITNNRLGNSRIYINGNLIDEKSISNLGDIHVSDNILFKIVGCNDTRYVGIRYFK
VFDTELGKTEIETLYSDEPDPSILKDFWGNYLLYNKRYYLLNLLRTDKSITQNSNFLNINQQRGVYQKPN
IFSNTRLYTGVEVIIRKNGSTDISNTDNFVRKNDLAYINVVDRDVEYRLYADISIAKPEKIIKLIRTSNS
NNSLGQIIVMDSIGNNCTMNFQNNNGGNIGLLGFHSNNLVASSWYYNNIRKNTSSNGCFWSFISKEHGWQ
EN

Epitope Information

IEDB Linear Epitope