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Env from strain FRA

General Information
Protegen ID 465
Sequence Strain (Species/Organism) Feline leukemia virus
VO ID VO_0011068
Taxonomy ID 11768
Molecule Role Protective antigen
Molecule Role Annotation Study describes experiments which demonstrate that the vaccine, (EURIFEL FeLV; Merial) that expresses the FeLV env and gag protective genes, is effective against any oronasal FeLV challenge. The protection was shown to be solid against an oronasal challenge one year after the initial vaccination, and was effective against a very severe 'in-contact' challenge (Poulet et al., 2003).
Related Vaccines(s) EURIFEL FeLV
References
Poulet et al., 2003: Poulet H, Brunet S, Boularand C, Guiot AL, Leroy V, Tartaglia J, Minke J, Audonnet JC, Desmettre P. Efficacy of a canarypox virus-vectored vaccine against feline leukaemia. The Veterinary record. 2003; 153(5); 141-145. [PubMed: 12934796].
Gene Information
Gene Name Env from strain FRA
NCBI Gene ID 1491868
Genbank Accession AF052723
Locus Tag FeLVgp2
Gene Starting Position 5987
Gene Ending Position 7915
DNA Sequence 
>NC_001940.1:5987-7915 Feline leukemia virus, complete genome
GATGGAAAGTCCAACGCACCCAAAACCCTCTAAAGATAAGACTCTCTCGTGGAACTTAGCGTTTCTGGTG
GGGATCTTATTCACAATAGACATAGGAATGGCCAATCCTAGTCCACACCAAATATATAATGTAACTTGGG
TAATAACCAATATGCAAACTAACACCCAAGCTAATGCCACCTCTATGTTAGGAACCTTAACCGATGCCTA
CCCTACCCTACATGTTGACCTATGTGACCTAGTGGGAGACACCTGGGAACCTATAGTCCTAGATCCAACC
AATGTAAAACACGGGGCACGTTACTCCTCCTCAAAGTATGGATGTAAAACTACAGATAGAAAAAAACAGC
AACAAACATACCCCTTTTACGTCTGCCCCGGACATGCCCCCTCGCTGGGGCCAAAGGGAACACATTGTGG
AGGGGCACAAGATGGGTTTTGTGCCGCATGGGGATGTGAGACCACCGGAGAAGCTTGGTGGAAGCCCTCC
TCCTCATGGGACTATATCACAGTAAAAAGAGGGAGTAGTCAGGACAATAGCTGTGAGGGAAAATGCAACC
CCCTGATTTTGCAGTTCACCCAGAAGGGAAGACAAGCCTCTTGGGACGGACCTAAGATATGGGGATTGCG
ACTATACCGTACAGGATATGACCCTATCGCCTTATTCACGGTGTCCCGGCAGGTGTCAGCCATTACGCCG
CCTCAGGCAATGGGACCAAACCTAGTCTTACCTGATCAAAAACCCCCATCCAGACAATCCCAAACAGGGT
CCAAAGTGGCGACCCAGAGGCTCCAAACGACTGAAAGCGCCCCAAGGTCTGTTGCCCCCACCACCGTGGG
TCCCAAACGGATTGGGACCGGAGATAGGTTAATAAATTTAGTACAAGGGACATACCTAGCCTTAAATGCC
ACCGACCCCAACAAAACTAAAGACTGTTGGCTCTGCCTGGTTTCTCGACCACCCTATTACGAAGGGATTG
CAATCTTAGGTAACTACAGCAACCAAACAAACCCCCCCCCATCCTGCCTATCTACTCCGCAACACAAACT
GACCATATCTGAAGTATCAGGGCAAGGACTGTGCATAGGGACTGTTCCTAAGACCCACCAGGCTTTGTGC
AATGAGACACAACAGGGACATACAGGGGCGCACTATCTAGCCGCCCCCAATGGCGCCTATTGGGCCTGTA
ACACTGGACTCACCCCATGCATTTCCATGGCGGTGCTCAATTGGACCTCTGATTTTTGTGTCTTAATCGA
ATTATGGCCCAGAGTGACTTACCATCAACCCGAATATGTGTACACACATTTTGCCAAAGCTGTCAGGTTC
CGAAGAGAACCAATATCACTAACTGTTGCCCTCATGTTGGGAGGACTCACTGTAGGGGGCATAGCCGCGG
GGGTCGGAACAGGGACTAAAGCCCTCCTTGAAACAGCCCAGTTCAGACAACTACAAATGGCCATGCACAC
AGACATCCAGGCCCTAGAAGAGTCAATTAGTGCCTTAGAAAAGTCCCTGACCTCCCTTTCTGAAGTAGTC
TTACAAAACAGACGGGGCCTAGATATTCTATTCTTACAAGAGGGAGGGCTCTGTGCCGCATTAAAAGAAG
AATGTTGCTTCTATGCGGATCACACCGGACTCGTCCGAGACAATATGGCTAAATTGAGAGAAAGACTAAA
ACAGCGGCAACAACTGTTTGACTCCCAACAGGGATGGTTTGAAGGATGGTTCAACAAGTCCCCCTGGTTC
ACAACCTTAATTTCCTCCATTATGGGCCCCTTACTAATCCTACTCCTAATTCTCCTCTTCGGCCCATGCA
TCCTTAACAGATTAGTACAATTCGTAAAAGACAGAATATCTGTGGTACAAGCCTTAATTTTAACCCAACA
GTACCAACAGATAAAGCAATACGATCCGGACCGACCATG
Protein Information
Protein Name Env polyprotein
NCBI Protein GI 9630709
Protein Accession NP_047256
Protein pI 8.36
Protein Weight 67586.88
Protein Length 642
Protein Sequence 
>NP_047256.1 Env polyprotein [Feline leukemia virus]
MESPTHPKPSKDKTLSWNLAFLVGILFTIDIGMANPSPHQIYNVTWVITNMQTNTQANATSMLGTLTDAY
PTLHVDLCDLVGDTWEPIVLDPTNVKHGARYSSSKYGCKTTDRKKQQQTYPFYVCPGHAPSLGPKGTHCG
GAQDGFCAAWGCETTGEAWWKPSSSWDYITVKRGSSQDNSCEGKCNPLILQFTQKGRQASWDGPKIWGLR
LYRTGYDPIALFTVSRQVSAITPPQAMGPNLVLPDQKPPSRQSQTGSKVATQRLQTTESAPRSVAPTTVG
PKRIGTGDRLINLVQGTYLALNATDPNKTKDCWLCLVSRPPYYEGIAILGNYSNQTNPPPSCLSTPQHKL
TISEVSGQGLCIGTVPKTHQALCNETQQGHTGAHYLAAPNGAYWACNTGLTPCISMAVLNWTSDFCVLIE
LWPRVTYHQPEYVYTHFAKAVRFRREPISLTVALMLGGLTVGGIAAGVGTGTKALLETAQFRQLQMAMHT
DIQALEESISALEKSLTSLSEVVLQNRRGLDILFLQEGGLCAALKEECCFYADHTGLVRDNMAKLRERLK
QRQQLFDSQQGWFEGWFNKSPWFTTLISSIMGPLLILLLILLFGPCILNRLVQFVKDRISVVQALILTQQ
YQQIKQYDPDRP
Epitope Information
IEDB Linear Epitope