VIOLIN: Vaccine Investigation and Online Information Network

gag

General Information

Protegen ID

466

Sequence Strain (Species/Organism)

Feline leukemia virus

VO ID

VO_0011069

Taxonomy ID

11768

Other Database IDs

CDD:307339
CDD:307969
CDD:197667

Molecule Role

Protective antigen

Molecule Role Annotation

The vaccine, (EURIFEL FeLV; Merial) that expresses the FeLV env and gag protective genes, is effective against any oronasal FeLV challenge. The protection was shown to be solid against an oronasal challenge one year after the initial vaccination, and was effective against a very severe 'in-contact' challenge (Poulet et al., 2003).

Related Vaccines(s)

ALVAC-FL- env/gag , EURIFEL FeLV

References

Poulet et al., 2003: Poulet H, Brunet S, Boularand C, Guiot AL, Leroy V, Tartaglia J, Minke J, Audonnet JC, Desmettre P. Efficacy of a canarypox virus-vectored vaccine against feline leukaemia. The Veterinary record. 2003; 153(5); 141-145. [PubMed: 12934796].

Gene Information

Gene Name

gag

Protein Information

Protein Name

gag-p15 polyprotein

NCBI Protein GI

323916

Protein pI

8.84

Protein Weight

55430.88

Protein Length

555

Protein Note

serogroup: B

Protein Sequence

>AAA43055.1 gag [Feline leukemia virus]
MGQTVTTPLSLTLDHWSEVRARAHNQGVEVRKKKWITLCEAEWVMMNVGWPREGTFSLDNISQVEKKIFA
PGPHGHPDQVPYITTWRSLATDPPSWVRPFLPPPKPPTPLPQPLSPQPSAPLTSSLYPVVPKPDPPKPPV
LPPDPSSPLIDLLTEEPPPYPGGHGPPPSGPRTPAASPIASRLRERRENPAEESQALPLREGPNNRPQYW
PFSASDLYNWKSHNPPFSQDPVALTNLIESILVTHQPTWDDCQQLLQALLTGEERQRVLLEARKQVPGED
GRPTQLPNVIDETFPLTRPNWDFATPAGREHLRLYRQLLLAGLRGAARRPTNLAQVKQVVQGKEETPAAF
LERLKEAYRMYTPYDPEDPGQAASVILSFIYQSSPDIRNKLQRLEGLQGFTLSDLLKEAEKIYNKRETPE
EREERLWQRQEERDKKRHKEMTKVLATVVAQNRDKDREENKLGDQRKIPLGKDQCAYCKEKGHWVRDCPK
RPRKKPANSTLLNLED

Epitope Information

IEDB Linear Epitope