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FopB

General Information
Protegen ID 468
Sequence Strain (Species/Organism) Francisella novicida U112
VO ID VO_0011070
Taxonomy ID 401614
Molecule Role Protective antigen
Molecule Role Annotation Intranasal immunization of HLA-DR4 tg mice with the single antigen FopB from F. tularensis subsp. novicida conferred significant protection against lethal pulmonary challenge with an F. tularensis subsp. holarctica live vaccine strain (Yu et al., 2010).
Additional Molecule Role Protective antigen
COG COG2825M, under M: Cell wall/membrane/envelope biogenesis
Related Vaccines(s) F. tularensis FopB Protein Vaccine
References
Yu et al., 2010: Yu JJ, Goluguri T, Guentzel MN, Chambers JP, Murthy AK, Klose KE, Forsthuber TG, Arulanandam BP. Francisella tularensis T-cell antigen identification using humanized HLA-DR4 transgenic mice. Clinical and vaccine immunology : CVI. 2010; 17(2); 215-222. [PubMed: 20016043].
Gene Information
Gene Name FopB
NCBI Gene ID 4547777
Genbank Accession CP000439
Locus Tag FTN_0119
Gene Starting Position 130543
Gene Ending Position 131082
DNA Sequence 
>NC_008601.1:130543-131082 Francisella tularensis subsp. novicida U112, complete genome
TATGAAAAAAACTATACTAGGAGCAATGATCGCTGGTGGTTTGATGGTTTCTGCAACTACAGCTATGGCT
GGTGGGGTAGGTTTTGCTAATGTCCAAGATATTTTTGAAACTTCACCTCTTGGTAAAGCAAAGGTAACAG
CTGATGAGAAAAAGCTAAAGCCACAGATGGACCAACTTAAGCAAAACATCACTGCTTTACAAGAGAAAGT
AAATGCATACACTCAAGAAAAAGATGATGTTCAAACAGATGATTCTAAAGGCGATACTAAAGATGCACAG
TCAGCAGACAAAGTAGAAAATCAAGATAAGCAACAAGCTCAAGCAGATCTTGAAAAAGCAATGAAAGATT
ACCAAAACCTAATGAATCAGGTTCAAAAAATGGCTTCTGACGATGCTGATGCGTTCAAAGATGCTTTGAC
TAAGGCTTCTGCTCAAGTTGCTAAAGAGAAGCAACTTGATGCTATTTTACCTGCTGAAATGAGTCTATAT
AATGTTGATAGTATTGATGTTACTAAAGATGTTATAGCTAAGATGCAATA
Protein Information
Protein Name hypothetical protein
NCBI Protein GI 118496734
Protein Accession YP_897784
Protein pI 4.55
Protein Weight 18246.3
Protein Length 179
Protein Sequence 
>YP_897784.1 hypothetical protein FTN_0119 [Francisella tularensis subsp. novicida U112]
MKKTILGAMIAGGLMVSATTAMAGGVGFANVQDIFETSPLGKAKVTADEKKLKPQMDQLKQNITALQEKV
NAYTQEKDDVQTDDSKGDTKDAQSADKVENQDKQQAQADLEKAMKDYQNLMNQVQKMASDDADAFKDALT
KASAQVAKEKQLDAILPAEMSLYNVDSIDVTKDVIAKMQ
Epitope Information
IEDB Linear Epitope