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IglB

General Information
Protegen ID 469
Sequence Strain (Species/Organism) Francisella novicida U112
VO ID VO_0011071
Taxonomy ID 401614
Molecule Role Virmugen
Molecule Role Annotation Intranasal vaccination with KKF235 (F. tularensis subsp. novicida mutant (DeltaiglB) ) protected mice from subsequent homotypic challenge with U112 as well as heterotypic challenge with F. tularensis subsp. holarctica (LVS). Most significantly, oral immunization with KKF235 protected mice from a highly lethal subsp. tularensis (SCHU S4) pulmonary challenge (Yu et al., 2010).
COG COG3517S, under S: Function unknown
Related Vaccines(s) Francisella tularensis IglB mutant vaccine
References
Yu et al., 2010: Yu JJ, Goluguri T, Guentzel MN, Chambers JP, Murthy AK, Klose KE, Forsthuber TG, Arulanandam BP. Francisella tularensis T-cell antigen identification using humanized HLA-DR4 transgenic mice. Clinical and vaccine immunology : CVI. 2010; 17(2); 215-222. [PubMed: 20016043].
Gene Information
Gene Name IglB
NCBI Gene ID 4548125
Genbank Accession CP000439
Locus Tag FTN_1323
Gene Starting Position 1397634
Gene Ending Position 1399154
DNA Sequence 
>gi|118496615:1397634-1399154 Francisella tularensis subsp. novicida U112, complete genome
TTTAGTTATTATTTGTACCGAATAATTCTGGTTCAAGCCTAGTATCTATAGTCATTGTAGTATTCATTCC
TTCAAATTGAATGTGGGGAATTACATTTATTTTGCATGAATACCAGCCAGGCTTACCCGGTATGGTTTTA
ACCTCGATAGAAACGTTTCTGAAAGGATATCTCGCCATTTCTAAAGGGGTTGGTTGATAGACTGTGGTGA
CAAATTCTGATATCCAATCAGAAAGAATTTTTTGAATCGACTCGACATCCACAATACTACCAATCTTATC
TCTAATTACACATTTAATATAATGAGATATTCTCGATATACACATAGTGTAAGAAAGGTTAGCAATTAAT
CTTGAGTTTGCTGAGTCAAATCCATCTACAAATTCTTCGACTTTTTTAGCAGAATTTACACTAAAGAAAC
AAGCGTTACTAGTACCTTTTTCACTTACAAATGGTATTAAACCAATATTTGCAAGTGATAACTCCATATA
ATCAGCAAATAATACATTTAGAGGTGACTTAGTTTCTAGAATGCCTTTATTATCATATACGCAAGCTACC
AAGTTTTTTACATAACCACCACTCTCAACTCCTCTTATATATTGGAACCATCTAGTTTTATCATAAGATC
TCATCATATTCTTAACTAGATGAATTGAAGCAGGTCCCCATAGATAACTTTCATTCTTATCATAATCAAC
AAACTCATTAAAGCCTTCCATAAGTTTATACTGAACTGGATTATTCTCAGGATTATATGGTTGCCGCAAC
ATAAAATCACCTACGGTCAAACCTATATATGCAGCAACATCAAGGTTTCTAAAATCATTCCACTCTTTAT
ATCTAGGATGCTCAAGCAAAGCTTCAAAACTTTTTATATGAGTGATTTCTGATAAATCCTTAACACCAAA
GAATGACTTATCAATTGATGCAATAAATGGTGCATGAGAATTCTTTGCCACCATACCCATTCCAGTCAAC
CAAATTATATCATTTGTGGTATTTTCAAAATTATACAATCCTAATATTGCGCCATAAGGTTCGCCACCAT
ATTGATCAAATTCTGAAACATATACTTTTTTGAAAAAGTCACTACTAGATATATCATATAAATTTCTCTC
GAAATCATATTGTAGCTCTTCTTTTTTTACATCTAATATACTTACTTCAACATTATCATAGTCTTCTTGA
CAAACCTCTTGCACCTTTAGCCATTCTTGCTCAAGTGCTCTAAACTCATCATTAGATATAATAGAGTTAA
CTTGTAAATCAATCAGCTTATCAATAACTGTAATAACTTTTTGAATATATTTTTGATTGTAATTATTTAT
ATTATCATTATTTGCTAATACCAAAGATAGCGCCATAAGGTTTCTAGCATTGTAGTCAGTAGATAAAGAT
AAAACTTTAGAAGCATCATCTGAAACATCAAAATCTATATTTTTGAGTACACTATCAACTTCTGTAGATC
CCCCAAAATTATTTAAAAGTTCATCAGTGAGACTTAATTTATTTATTGTCA
Protein Information
Protein Name intracellular growth locus protein B
NCBI Protein GI 118497903
Protein Accession YP_898953
Protein pI 4.5
Protein Weight 54019.41
Protein Length 506
Protein Sequence 
>gi|118497903|ref|YP_898953.1| intracellular growth locus protein B [Francisella tularensis subsp. novicida U112]
MTINKLSLTDELLNNFGGSTEVDSVLKNIDFDVSDDASKVLSLSTDYNARNLMALSLVLANNDNINNYNQ
KYIQKVITVIDKLIDLQVNSIISNDEFRALEQEWLKVQEVCQEDYDNVEVSILDVKKEELQYDFERNLYD
ISSSDFFKKVYVSEFDQYGGEPYGAILGLYNFENTTNDIIWLTGMGMVAKNSHAPFIASIDKSFFGVKDL
SEITHIKSFEALLEHPRYKEWNDFRNLDVAAYIGLTVGDFMLRQPYNPENNPVQYKLMEGFNEFVDYDKN
ESYLWGPASIHLVKNMMRSYDKTRWFQYIRGVESGGYVKNLVACVYDNKGILETKSPLNVLFADYMELSL
ANIGLIPFVSEKGTSNACFFSVNSAKKVEEFVDGFDSANSRLIANLSYTMCISRISHYIKCVIRDKIGSI
VDVESIQKILSDWISEFVTTVYQPTPLEMARYPFRNVSIEVKTIPGKPGWYSCKINVIPHIQFEGMNTTM
TIDTRLEPELFGTNNN
Epitope Information
IEDB Linear Epitope