VIOLIN: Vaccine Investigation and Online Information Network

IglC1

General Information

Protegen ID

470

Sequence Strain (Species/Organism)

Francisella tularensis subsp. tularensis SCHU S4

VO ID

VO_0011072

Taxonomy ID

177416

Molecule Role

Protective antigen

Molecule Role Annotation

Mice immunized with rLm/iglC were protected against lethal challenge with F. tularensis LVS administered by the intranasal route, a route chosen to mimic airborne infection, and, most importantly, against aerosol challenge with the highly virulent Type A F. tularensis SchuS4 strain (Jia et al., 2009).

Related Vaccines(s)

F. tularensis vaccine rLm/iglC

References

Jia et al., 2009: Jia Q, Lee BY, Clemens DL, Bowen RA, Horwitz MA. Recombinant attenuated Listeria monocytogenes vaccine expressing Francisella tularensis IglC induces protection in mice against aerosolized Type A F. tularensis. Vaccine. 2009; 27(8); 1216-1229. [PubMed: 19126421].

Gene Information

Gene Name

IglC1

NCBI Gene ID

3191591

Genbank Accession

AJ749949

Locus Tag

FTT_1357c

Gene Starting Position

1398637

Gene Ending Position

1399272

DNA Sequence

>NC_006570.2:1398637-1399272 Francisella tularensis subsp. tularensis SCHU S4 chromosome, complete genome
ACTATGCAGCTGCAATATATCCTATTTTAGCAACTCCTTTATCTGTGCTAGCTGCGCAACATACTGGCAA
ACTTCCTTGAGATGTTGTAAGACCATCTATAGATATAATATGATATCTCATTCCATCTTTTGAAACACCC
ATAAGTTCTGTTGGCTCTATACTAATACTAAAAGCCTTAGCACTTATTGGATATAACTCTAAATTAGATA
GATCTATCATAATACCCCATGCTTCATCAGTTTTATACTCTTGTTTTTTATTAGAATTACCTAACTTAAT
TTTCATATCTGTAGCACTTGCTTGTAATATACTCGAAACTTTCTCTTCAATTTTAGTTCTAACATTTGAT
TTAATTAGAACACCAAGAGTAATACTTATTGTTGGATTTATAGAGCCTGGCGTTATAGATAAACGTATTA
CACTAGCAGCAGCTGTAGCCGAATCAGCTTTCGTGACATCCTCTCCACCATCTATAGCAACGATATTTTT
ATCAAGTTTCTCCCCAGCTATAGTTAAAGAATCAATAAATAATCTACAATTAGGATGAGATCCTATACAT
GCAGTAGGATCAGTTCTCACATGAATGGTCTCGCCACTTGTTACCTGTTGTCTTGTTATCATCTCACTCA
TAATCA

Protein Information

Protein Name

intracellular growth locus subunit C

NCBI Protein GI

56708413

Protein Accession

YP_170309

3D structure: PDB ID

2QWU

Protein pI

6.26

Protein Weight

21340.81

Protein Length

211

Protein Note

Similar to AAP58964.1 (Q7X3J5) IglC (23 kDa protein) from Francisella novicida (211 aa). BLAST Score = 405, Expect = e-112 Identities = 209/211 (99), Positives = 210/211 (99) Identical to FTT1712. It is part of the duplicated region 1374371..1408281 which is identical to 1767715..1801625

Protein Sequence

>YP_170309.1 intracellular growth locus subunit C [Francisella tularensis subsp. tularensis SCHU S4]
MIMSEMITRQQVTSGETIHVRTDPTACIGSHPNCRLFIDSLTIAGEKLDKNIVAIDGGEDVTKADSATAA
ASVIRLSITPGSINPTISITLGVLIKSNVRTKIEEKVSSILQASATDMKIKLGNSNKKQEYKTDEAWGIM
IDLSNLELYPISAKAFSISIEPTELMGVSKDGMRYHIISIDGLTTSQGSLPVCCAASTDKGVAKIGYIAA
A

Epitope Information

IEDB Linear Epitope