VIOLIN: Vaccine Investigation and Online Information Network

IglC2

General Information

Protegen ID

471

Sequence Strain (Species/Organism)

Francisella tularensis subsp. tularensis SCHU S4

VO ID

VO_0011073

Taxonomy ID

177416

Molecule Role

Protective antigen

Molecule Role Annotation

Mice immunized with rLm/iglC were protected against lethal challenge with F. tularensis LVS administered by the intranasal route, a route chosen to mimic airborne infection, and, most importantly, against aerosol challenge with the highly virulent Type A F. tularensis SchuS4 strain (Jia et al., 2009).

Related Vaccines(s)

F. tularensis vaccine rLm/iglC

References

Jia et al., 2009: Jia Q, Lee BY, Clemens DL, Bowen RA, Horwitz MA. Recombinant attenuated Listeria monocytogenes vaccine expressing Francisella tularensis IglC induces protection in mice against aerosolized Type A F. tularensis. Vaccine. 2009; 27(8); 1216-1229. [PubMed: 19126421].

Gene Information

Gene Name

IglC2

NCBI Gene ID

3191814

Genbank Accession

AJ749949

Locus Tag

FTT_1712c

Gene Starting Position

1791972

Gene Ending Position

1792607

DNA Sequence

>NC_006570.2:1791972-1792607 Francisella tularensis subsp. tularensis SCHU S4 chromosome, complete genome
ACTATGCAGCTGCAATATATCCTATTTTAGCAACTCCTTTATCTGTGCTAGCTGCGCAACATACTGGCAA
ACTTCCTTGAGATGTTGTAAGACCATCTATAGATATAATATGATATCTCATTCCATCTTTTGAAACACCC
ATAAGTTCTGTTGGCTCTATACTAATACTAAAAGCCTTAGCACTTATTGGATATAACTCTAAATTAGATA
GATCTATCATAATACCCCATGCTTCATCAGTTTTATACTCTTGTTTTTTATTAGAATTACCTAACTTAAT
TTTCATATCTGTAGCACTTGCTTGTAATATACTCGAAACTTTCTCTTCAATTTTAGTTCTAACATTTGAT
TTAATTAGAACACCAAGAGTAATACTTATTGTTGGATTTATAGAGCCTGGCGTTATAGATAAACGTATTA
CACTAGCAGCAGCTGTAGCCGAATCAGCTTTCGTGACATCCTCTCCACCATCTATAGCAACGATATTTTT
ATCAAGTTTCTCCCCAGCTATAGTTAAAGAATCAATAAATAATCTACAATTAGGATGAGATCCTATACAT
GCAGTAGGATCAGTTCTCACATGAATGGTCTCGCCACTTGTTACCTGTTGTCTTGTTATCATCTCACTCA
TAATCA

Protein Information

Protein Name

intracellular growth locus subunit C

NCBI Protein GI

56708721

Protein Accession

YP_170617

Protein pI

6.26

Protein Weight

21340.81

Protein Length

211

Protein Note

Similar to AAP58964.1 (Q7X3J5) IglC from Francisella novicida (23 kDa protein) (211 aa). BLAST Score = 405,Expect = e-112 Identities = 209/211 (99), Positives = 210/211 (99). Identical to FTT1357. It is part of the duplicated region 1767715..1801625 which is identical to 1374371..1408281

Protein Sequence

>YP_170617.1 intracellular growth locus subunit C [Francisella tularensis subsp. tularensis SCHU S4]
MIMSEMITRQQVTSGETIHVRTDPTACIGSHPNCRLFIDSLTIAGEKLDKNIVAIDGGEDVTKADSATAA
ASVIRLSITPGSINPTISITLGVLIKSNVRTKIEEKVSSILQASATDMKIKLGNSNKKQEYKTDEAWGIM
IDLSNLELYPISAKAFSISIEPTELMGVSKDGMRYHIISIDGLTTSQGSLPVCCAASTDKGVAKIGYIAA
A

Epitope Information

IEDB Linear Epitope