VIOLIN: Vaccine Investigation and Online Information Network

groEL

General Information

Protegen ID

473

Sequence Strain (Species/Organism)

Francisella tularensis

VO ID

VO_0011075

Taxonomy ID

510831

Other Database IDs

CDD:234573
CDD:239460

Molecule Role

Protective antigen

Molecule Role Annotation

Researchers have shown that mice that had been immunized with purified heat shock protein 60 (Hsp60, groEL) isolated from Francisella tularensis were protected against a subsequent challenge with some strains of the bacterium (Hartley et al., 2004).

Related Vaccines(s)

F. tularensis GroEL protein vaccine

References

Hartley et al., 2004: Hartley MG, Green M, Choules G, Rogers D, Rees DG, Newstead S, Sjostedt A, Titball RW. Protection afforded by heat shock protein 60 from Francisella tularensis is due to copurified lipopolysaccharide. Infection and immunity. 2004; 72(7); 4109-4113. [PubMed: 15213156].

Gene Information

Gene Name

groEL

Protein Information

Protein Name

chaperonin GroEL

NCBI Protein GI

282159959

Protein pI

4.6

Protein Weight

53514.52

Protein Length

634

Protein Note

chaperonin GroEL; Reviewed; PRK00013

Protein Sequence

>ADA79350.1 chaperonin GroEL [Francisella tularensis subsp. tularensis NE061598]
MAAKQVLFSDEARAKMLDGVNTLANAVKVTLGPKGRNVVLDKSFGTPTITKDGVSVAKEIELEDKFENMG
AQIVKEVASKTADVAGDGTTTATVLAQALLTEGLKAVAAGMNPMDLKRGIDKATARLVEELKALSKPCSD
PKSIEQVGTISANSDATVGKLIADAMAKVGKEGVITVEEGKGFEDELDVVEGMQFDRGYLSPYFATNQEN
MTTDLENPYILIVDKKISNIRDLLPILEGVSKSGRALLIIAEDVESEALATLVVNNMRGVVKVCAVKAPG
FGDRRKAMLEDIATLTGATFVSEDLSMKLEETNMEHLGTASRVQVTKDNTTIIDGAGEKEAIAKRINVIK
ANIAEANSDYDREKLQERLAKLSGGVAVIKVGAVTEAEMKEKKDRVDDALHATRAAVEEGIVAGGGVALI
RAQKALDGLTGENDDQNYGIALLRKAIEAPLRQIVSNAGGESSVVVNQVKANQGNYGYNAANDTYGDMVE
MGILDPTKVTRSALQHAASIAGLMITTEAMIGEIKEAAPAMPMGGGMGGMPGMM

Epitope Information

IEDB Linear Epitope