VIOLIN: Vaccine Investigation and Online Information Network

FopA

General Information

Protegen ID

476

Sequence Strain (Species/Organism)

Francisella tularensis subsp. holarctica OSU18

VO ID

VO_0011078

Taxonomy ID

393011

Molecule Role

Protective antigen

Molecule Role Annotation

Anti-FopA MAbs protected 90% of naïve C3H/HeN mice from lethal challenge with F. tularensis LVS when administered prophylactically as well as therapeutically (Savitt et al., 2009).

COG

COG2885M, under M: Cell wall/membrane/envelope biogenesis

References

Savitt et al., 2009: Savitt AG, Mena-Taboada P, Monsalve G, Benach JL. Francisella tularensis infection-derived monoclonal antibodies provide detection, protection, and therapy. Clinical and vaccine immunology : CVI. 2009; 16(3); 414-422. [PubMed: 19176692].

Gene Information

Gene Name

FopA

NCBI Gene ID

4306351

Genbank Accession

CP000437

Locus Tag

FTH_1293

Gene Starting Position

1267837

Gene Ending Position

1269018

DNA Sequence

>NC_008369.1:1267837-1269018 Francisella tularensis subsp. holarctica OSU18, complete genome
ATTAGTTAGCTTCTTTAAGTGGAGCTGATACGCTAGCTTCTACACGCTGGTTACGCGGATCAGACTTATG
AATACCACCTAAAGTATCATTATAGCCAAAACCTTTAGTAATTATTTTCTCACTATCTAAACCTAATTGC
TTCATGTAATCAGCAACAGCTTGTGCTCTCTTCTCAGAAAGTTTTTGGTTATATATATCAAACTCACTAC
CAGTTTGACCTTGAGAAGCATAACCTTTAACTGTTACAGAGCTAATGTTACTATCCTTGATAAAATTAAC
AAAAGATGCAATAGCTTTTTTACCTTTAGCATTTAAAGTAGCTTTATCATAAGCAAACTTAGTATCTAGG
TAAACTGTTACATCATCACCATTTACTGTATAGCACGCGACACCATCTTCAGTTAGATTAAAGTTGCCTT
CACATTGCTTAATACCAGCAGGTAAAACATACTTAGACTCATCAATAGTTGGCATAGCAACAGTTTGAGC
AGCTGTAGTCGCACCATTATCCTGAATATTACCAGTGTCATTATTAGTAGTATCTTTGCCACCAAAGAAC
CATGTTAAACCAGCACCAATCATGTTAGTACCCGCTCTGCCATTAGCACCAGAAATATTACTAGGTGCCA
TTGTTTGGATATATCTGTAGTCAACACTTGCTTGAACATTTCTAGATAGTTCAAACTTAAGACCACCACC
CACATCCCAAGCACCTGTTGCTTGACCTGCTAGATTTGCCCAACCAGCACCACCTGCAGCATATGGAGTA
AACATAGTATTATTACTAAAGTTTACAACACCTTCACCTAAACCAGCAAATACTCTACCAACTAATTGGT
TGTACTGTACAGCGAAGTATTTATTGATGTTATAACCGATTGTGAAGTTAGCACCAGCACCTGATGGAGA
GTTAGGAGTTCCAGCTAGACCGTTAGCATCTACACCTAAGTACCACTGGCCAGTTCTATCTTGAGGACCC
CAAGTATTGTCCTTGTTAGTCAAAGCGCTATAAGTATTTGCAAAAGGAGCAATGAAATTATTAGCTGCAA
AACCACTGCTTTGTGTAGTAGCTGAATTAGAGTTTGCTGACGTATCGATATTATCTGAACCTGCAGCGAT
AGATGCTGTAGCTGAACCTAATAATACAGTTGTAGCTATAACAATACTTTTTAATCTCATCA

Protein Information

Protein Name

outer membrane protein FopA

NCBI Protein GI

115315051

Protein Accession

YP_763774

Protein pI

5.43

Protein Weight

39079.73

Protein Length

393

Protein Sequence

>YP_763774.1 outer membrane protein FopA [Francisella tularensis subsp. holarctica OSU18]
MMRLKSIVIATTVLLGSATASIAAGSDNIDTSANSNSATTQSSGFAANNFIAPFANTYSALTNKDNTWGP
QDRTGQWYLGVDANGLAGTPNSPSGAGANFTIGYNINKYFAVQYNQLVGRVFAGLGEGVVNFSNNTMFTP
YAAGGAGWANLAGQATGAWDVGGGLKFELSRNVQASVDYRYIQTMAPSNISGANGRAGTNMIGAGLTWFF
GGKDTTNNDTGNIQDNGATTAAQTVAMPTIDESKYVLPAGIKQCEGNFNLTEDGVACYTVNGDDVTVYLD
TKFAYDKATLNAKGKKAIASFVNFIKDSNISSVTVKGYASQGQTGSEFDIYNQKLSEKRAQAVADYMKQL
GLDSEKIITKGFGYNDTLGGIHKSDPRNQRVEASVSAPLKEAN

Epitope Information

IEDB Linear Epitope