VIOLIN: Vaccine Investigation and Online Information Network

OmpP5

General Information

Protegen ID

482

Sequence Strain (Species/Organism)

Haemophilus influenzae 86-028NP

VO ID

VO_0011082

Taxonomy ID

281310

Molecule Role

Protective antigen

Molecule Role Annotation

In a chinchilla model of otitis media, initial screening of P5-fimbrin, delivered singly or in combination with either Freund's adjuvant or alum, indicated that augmented bacterial clearance from the nasopharynx, the middle ears, or both anatomical sites could be induced by parenteral immunization with P5-fimbrin combined with lipoprotein D, lipoprotein D alone, or the synthetic chimeric peptide LB1 (derived from P5-fimbrin), respectively (Bakaletz et al., 1999).

COG

COG2885M, under M: Cell wall/membrane/envelope biogenesis

References

Bakaletz et al., 1999: Bakaletz LO, Kennedy BJ, Novotny LA, Duquesne G, Cohen J, Lobet Y. Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection. Infection and immunity. 1999; 67(6); 2746-2762. [PubMed: 10338477].

Gene Information

Gene Name

OmpP5

NCBI Gene ID

3430592

Genbank Accession

CP000057

Locus Tag

NTHI1332

Gene Starting Position

1268384

Gene Ending Position

1269463

DNA Sequence

>NC_007146.2:1268384-1269463 Haemophilus influenzae 86-028NP, complete genome
AATGAAAAAAACTGCAATCGCATTAGTAGTTGCTGGCTTAGCAGCAGCTTCAGTAGCTCAAGCAGCTCCA
CAAGAAAATACTTTCTACGCAGGCGTTAAAGCTGGTCAAGGATCTTTCCATGATGGTATTAACAATAATG
GCGCAATTAAACAGAATTTATCATCTGCTAATTATGGTTACAGACGCAATACTTTCACTTATGGTGTATT
TGGTGGTTACCAAATTTTAAATCAAGATAATTTTGGTTTAGCTGCTGAATTAGGTTACGACAATTTTGGC
CGTGTAAAACTTCGTGAAGCAGGAAAACCTAAAGCTAAACATACTAACCACGGTGCGCACTTAAGCTTAA
AAGGCAGCTATGAAGTGTTAGACGGTTTAGATGTTTATGGCAAAGCAGGTGTTGCTTTAGTACGTTCTGA
TTATAAATTTTATGAAGTTGCAAACGGTACTCGTGACCACAAGAAAGGTCGTCACACAGCACGTGCCTCT
GGTTTATTTGCAGTAGGTGCAGAATACGCAGTATTACCAGAATTAGCAGTTCGTTTAGAATACCAATGGC
TAACTCGCGTAGGTAAATACCGCCCTCAAGATAAACCAAATACCGCAATTAACTACAACCCTTGGATTGG
TTCTATCAATGCGGGTATTTCTTACCGTTTCGGTCAAGGCGAAGCACCAGTTGTTGCAGCACCTGAAATG
GTAAGCAAAACTTTCAGCTTAAATTCTGATGTAACTTTCGCATTTGGTAAAGCAAACTTAAAACCTCAAG
CACAAGCAACATTAGACAGCGTCTATGGCGAAATTTCACAAGTTAAAAGTGCAAAAGTAGCTGTTGCTGG
TTACACTGACCGTATTGGTTCTGACGCGTTCAACGTAAAACTTTCTCAAGAACGTGCAGATTCAGTAGCT
AACTACTTTGTTGCTAAAGGTGTTGCAGCAGACGCAATCTCTGCAACTGGCTACGGTAAAGCAAACCCAG
TAACTGGTGCAACTTGTGACCAAGTTAAAGGTCGTAAAGCGCTTATCGCTTGTCTTGCTCCAGACCGTCG
TGTAGAAATCGCGGTAAACGGTACTAAATA

Protein Information

Protein Name

outer membrane protein P5

NCBI Protein GI

68249712

Protein Accession

YP_248824

Protein pI

9.95

Protein Weight

35189.54

Protein Length

359

Protein Note

Similar to: HI1164, OM53_HAEIN

Protein Sequence

>YP_248824.1 outer membrane protein P5 [Haemophilus influenzae 86-028NP]
MKKTAIALVVAGLAAASVAQAAPQENTFYAGVKAGQGSFHDGINNNGAIKQNLSSANYGYRRNTFTYGVF
GGYQILNQDNFGLAAELGYDNFGRVKLREAGKPKAKHTNHGAHLSLKGSYEVLDGLDVYGKAGVALVRSD
YKFYEVANGTRDHKKGRHTARASGLFAVGAEYAVLPELAVRLEYQWLTRVGKYRPQDKPNTAINYNPWIG
SINAGISYRFGQGEAPVVAAPEMVSKTFSLNSDVTFAFGKANLKPQAQATLDSVYGEISQVKSAKVAVAG
YTDRIGSDAFNVKLSQERADSVANYFVAKGVAADAISATGYGKANPVTGATCDQVKGRKALIACLAPDRR
VEIAVNGTK

Epitope Information

IEDB Linear Epitope