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D15

General Information
Protegen ID 483
Sequence Strain (Species/Organism) Haemophilus influenzae 86-028NP
VO ID VO_0011083
Taxonomy ID 281310
Molecule Role Protective antigen
Molecule Role Annotation Purified rD15 was found to be highly immunogenic in mice, guinea pigs, and rabbits, and passive transfer of anti-rD15 antibodies protected infant rats from challenge with H. influenzae type b or type a in infant rat models of bacteremia (Loosmore et al., 1997).
COG COG4775M, under M: Cell wall/membrane/envelope biogenesis
Related Vaccines(s) H. influenzae D15 protein vaccine
References
Loosmore et al., 1997: Loosmore SM, Yang YP, Coleman DC, Shortreed JM, England DM, Klein MH. Outer membrane protein D15 is conserved among Haemophilus influenzae species and may represent a universal protective antigen against invasive disease. Infection and immunity. 1997; 65(9); 3701-3707. [PubMed: 9284140].
Gene Information
Gene Name D15
NCBI Gene ID 3430379
Genbank Accession CP000057
Locus Tag NTHI1084
Gene Starting Position 1030831
Gene Ending Position 1033233
DNA Sequence 
>NC_007146.2:1030831-1033233 Haemophilus influenzae 86-028NP, complete genome
ATTAGAAAGAACCTCCAATACTAAATTGGAACTGTTCGACATCATCATTTTCATATTTTTTAATTGGTTT
GGCATAAGAGAATACCAATGGCCCAATAGGAGATTGCCATTGGAATCCGACACCTGTAGAGGCGCGAATA
CGGCTTGATTTGCCATAATCGGGTAAGCTTTTTAATACATTGTTATCTAACCCACTCTTATCCGATTTCC
ACTTAGTATTCCAAACACTTGCCGCATCAACAAATAGGGAAGTTCGGACCGTATTTTGGCTCTTATCGCT
CACAAACGGTGTTGGTACAATAAGTTCTGCACTCGCAGTTGTGATTGCATTACCACCAATCACATCAGAA
CTTATCTTATTAAAAGTACCATTACTATTACTATTACTATTACCATTTTGAGCGGCATAAATTGCGTTAG
GTCCAATACTACCATAAGCAAAACCACGTAATGAACCGATGCCACCCGCTGTATAAGTTTGATAGAACGG
TAAACGCTTGTTTCCAAAACCATTTGCATATCCTGCAGATGCTTTTGCAGATACAACCCAGAGGTGATCT
CTGTCTAATGGGTAGAAACCCTGTACATCTGCACTTAGTTTGTAGTATTTGTTATCAGAACCTGGAATAG
TAACTCGTCCACCAAGACTTGCTTTAACCCCTTTAGTTGGGAAATAGCCTCTATTAAGGCTGTTATAGTT
CCAACCAAAAGAAAAATCAAAGTCATTTGTTTTAATGCCATTACCTTTAAATTTCATTGATTGAATATAT
AAATTACGGTTATATTCTAGAGCAAAGTTACTAATTTTATTATAGGTATGGCCTAATCCTACATAATAGG
AGTTATTTTCATTTACAGGGAAACCTAAAGTAACATTACTTCCATAAGTCGTACGCTTATAGTTAGAGGA
TGTATCACTTTTAGAGTTATCGTAGTTTTCAAAGAAAACATTTCCACCAAGACTTACACCATCTTTAGTA
AAATAGGGCTCGGTATAACCCAAATTGACACTCGTACCATAATCATTTTTCGTACCAGCTATACTTACTG
CAGCCCCTGTTCCTAAGAAATTATCTTGTTTAACACTTGCTTGATAACTAATACCACTCTCTGTACCGTA
ACCAATACCAAAGTTGATACTACCCGTGTTACGTTCTTTGACTTTATATACGACATCCACTTCATCATTG
CTACCATTGATAGGATCAATTCGGTTTTCGACTGTTTCGAAGAAACCTGTACGATCTAAGCGAATTTTTC
CTAACTCAACTAATTGTGAATTATACCAAGTTCCTTCTTGTTGGCGCATTTCCTGACGTAAAGTGCTATC
AGCAGAAACGGTATTTCCTTCAAAGCGAAGTTGGCGAACAGTTAAACGTCGTCCAGCATCAACAACAAGG
GTTATCGCTAATGTTTTATTTGCATCATCAAAATCAGGTACTGAATTTACCGTTGCGCTACCGTAACCGC
GTTCTCCAAGTTTTGCTTTAATTGCATTTTCTACATCTGCAATATCACTACGGCGGAAAGTATCATTTAA
ATGTAATGCTGAAAGTAAAGGTTCAAGCTCGGCAGACATACCTCCCAGATTACCTATAATGCGTGCACTA
CGAAGGTCATACTGTAAACCTTCATTTACATCAATGGTTACATTAACTTTTGTTTTTTCATCATTTAGCT
GAACATCCGTTTTAGTAATTTGTGCTTTGGCATAGCCATTATTTAAATAATAATCACGAATTGACTGCAA
ATCTTTCTCGAATTGCGCACCTTCAAATTTATTTCCCCATAATTTCCACCAAGAATCAGGTTGTAATTCC
ATTTGTTCTTGTAATGTACTGCTACTAACAGATTCGTTCCCCTTGAAAGTTAATGATGCCAATTTTGCTT
TATCATCTTCATTGATTTGAATTAAAATTTCAGCGCGATTATTTGGTAGCGTATTGACAATAGGTTCAAC
GGTTGCGTTATAGCGACCTACACTTGCATAGTGTTCTTTTACACTTTTGGCAAATTCATTTAATTTTTCT
CGAATTAAAACATCGCCAACTTTAAACCCGTTAGCATCTAAGTTTTGTTTTAGTGCTTCAGTGGGAATAA
TAGAGTTACCTTTGATTTTAACATCTGAAATGATCGATTTAGCCACAACGCTAACAACAAGCACATCGCC
TTCTTGATGCGCTTTCACATCATCGAATCGACCACTTACGAATAAAGAGCGGACAATATTAGCCACATCA
TTGTCAGTCACACGCTGACCGGCACGAACAGGTAAACTTGCTCGGATTTGTTGTTTTAAGTCACCTTGAA
CACCATCCACACGAATATCTTTTGCCACAAAAGGTGCGGCAAACACAGTCGTTGTCGTACCGAATAATAA
ACTTGCGATTAGAAGTTTTTTCA
Protein Information
Protein Name protective surface antigen D15
NCBI Protein GI 68249503
Protein Accession YP_248615
Protein pI 8.84
Protein Weight 81691.94
Protein Length 800
Protein Note Similar to: HI0917, D152_HAEIN
Protein Sequence 
>YP_248615.1 protective surface antigen D15 [Haemophilus influenzae 86-028NP]
MKKLLIASLLFGTTTTVFAAPFVAKDIRVDGVQGDLKQQIRASLPVRAGQRVTDNDVANIVRSLFVSGRF
DDVKAHQEGDVLVVSVVAKSIISDVKIKGNSIIPTEALKQNLDANGFKVGDVLIREKLNEFAKSVKEHYA
SVGRYNATVEPIVNTLPNNRAEILIQINEDDKAKLASLTFKGNESVSSSTLQEQMELQPDSWWKLWGNKF
EGAQFEKDLQSIRDYYLNNGYAKAQITKTDVQLNDEKTKVNVTIDVNEGLQYDLRSARIIGNLGGMSAEL
EPLLSALHLNDTFRRSDIADVENAIKAKLGERGYGSATVNSVPDFDDANKTLAITLVVDAGRRLTVRQLR
FEGNTVSADSTLRQEMRQQEGTWYNSQLVELGKIRLDRTGFFETVENRIDPINGSNDEVDVVYKVKERNT
GSINFGIGYGTESGISYQASVKQDNFLGTGAAVSIAGTKNDYGTSVNLGYTEPYFTKDGVSLGGNVFFEN
YDNSKSDTSSNYKRTTYGSNVTLGFPVNENNSYYVGLGHTYNKISNFALEYNRNLYIQSMKFKGNGIKTN
DFDFSFGWNYNSLNRGYFPTKGVKASLGGRVTIPGSDNKYYKLSADVQGFYPLDRDHLWVVSAKASAGYA
NGFGNKRLPFYQTYTAGGIGSLRGFAYGSIGPNAIYAAQNGNSNSNSNGTFNKISSDVIGGNAITTASAE
LIVPTPFVSDKSQNTVRTSLFVDAASVWNTKWKSDKSGLDNNVLKSLPDYGKSSRIRASTGVGFQWQSPI
GPLVFSYAKPIKKYENDDVEQFQFSIGGSF
Epitope Information
IEDB Linear Epitope