VIOLIN: Vaccine Investigation and Online Information Network

SNVsSgp1

General Information

Protegen ID

489

Sequence Strain (Species/Organism)

Sin Nombre orthohantavirus

VO ID

VO_0011087

Taxonomy ID

1980491

Molecule Role

Protective antigen

Molecule Role Annotation

Study used a deer mouse infection model to test the protective efficacy of genetic vaccine candidates for Sin Nombre (SN) virus that were known to provoke immunological responses in BALB/c mice. Protective epitopes were localized in each of four overlapping cDNA fragments that encoded portions of the SN virus G1 glycoprotein antigen; the nucleocapsid gene (SNVsSgp1) also was protective (Bharadwaj et al., 2002).

Related Vaccines(s)

Sin Nombre virus DNA vaccine encoding SNVsSgp1 (NP)

References

Bharadwaj et al., 2002: Bharadwaj M, Mirowsky K, Ye C, Botten J, Masten B, Yee J, Lyons CR, Hjelle B. Genetic vaccines protect against Sin Nombre hantavirus challenge in the deer mouse (Peromyscus maniculatus). The Journal of general virology. 2002; 83(Pt 7); 1745-1751. [PubMed: 12075094].

Gene Information

Gene Name

SNVsSgp1

NCBI Gene ID

2943142

Genbank Accession

JQ690276

Locus Tag

SNVsSgp1

Segment No

segment S

Gene Starting Position

Gene Ending Position

1328

DNA Sequence

>NC_005216.1:42-1328 Sin Nombre virus segment S, complete sequence
AATGAGCACCCTCAAAGAAGTGCAAGACAACATCACTCTCCACGAACAACAACTCGTGACTGCCAGGCAG
AAGCTCAAAGATGCAGAAAGAGCGGTGGAATTGGACCCCGATGATGTTAACAAAAGCACATTACAGAGCA
GACGGGCAGCTGTGTCTGCATTGGAGACCAAACTCGGAGAACTTAAGCGGGAACTGGCTGATCTTATTGC
AGCTCAGAAATTGGCTTCAAAACCTGTTGATCCAACAGGGATTGAACCTGATGACCATCTAAAGGAAAAG
TCATCATTGAGATATGGAAATGTCCTTGATGTAAATTCCATTGACTTAGAAGAGCCAAGTGGGCAAACAG
CTGATTGGAAATCCATCGGACTCTACATTCTAAGTTTCGCATTACCGATTATTCTTAAAGCCTTGTACAT
GTTATCTACTAGGGGCCGTCAAACAATCAAAGAAAACAAGGGAACAAGAATTCGATTCAAGGATGATTCA
TCTTATGAAGAAGTCAATGGGATACGTAAGCCAAGACATCTGTATGTTTCTATGCCAACTGCCCAGTCTA
CAATGAAAGCAGATGAGATTACTCCCGGGAGGTTCCGTACAATTGCTTGTGGATTATTCCCAGCCCAAGT
CAAAGCAAGGAATATTATCAGTCCTGTCATGGGTGTGATTGGCTTTAGTTTTTTTGTGAAAGATTGGATG
GAAAGGATTGATGACTTCCTGGCTGCACGTTGCCCATTTCTGCCTGAGCAGAAAGACCCTAGAGATGCTG
CATTGGCAACTAATAGAGCCTATTTTATAACACGTCAATTACAGGTTGATGAGTCAAAGGTTAGTGATAT
TGAGGACCTGATTGCTGATGCAAGGGCTGAGTCTGCCACTATATTCGCAGATATTGCTACTCCTCATTCA
GTTTGGGTCTTTGCATGTGCTCCAGATCGTTGTCCACCTACAGCATTATATGTGGCCGGGATGCCGGAAC
TGGGTGCATTTTTTGCTATTCTCCAGGATATGAGGAACACCATAATGGCATCCAAATCTGTGGGGACATC
TGAAGAGAAATTGAAGAAGAAATCAGCATTCTACCAGTCATACTTAAGACGTACTCAGTCAATGGGAATT
CAACTGGACCAGAAGATAATCATCTTATACATGAGCCATTGGGGAAGAGAGGCCGTGAATCACTTCCATC
TTGGAGATGATATGGATCCTGAGCTTAGGGAACTTGCCCAGACCCTTGTAGATATCAAGGTCAGGGAAAT
CTCTAACCAAGAACCACTTAAACTTTA

Protein Information

Protein Name

nucleocapsid protein

NCBI Protein GI

38371726

Protein Accession

NP_941975

Protein pI

6.64

Protein Weight

45894.2

Protein Length

428

Protein Note

putative

Protein Sequence

>NP_941975.1 nucleocapsid protein [Sin Nombre orthohantavirus]
MSTLKEVQDNITLHEQQLVTARQKLKDAERAVELDPDDVNKSTLQSRRAAVSALETKLGELKRELADLIA
AQKLASKPVDPTGIEPDDHLKEKSSLRYGNVLDVNSIDLEEPSGQTADWKSIGLYILSFALPIILKALYM
LSTRGRQTIKENKGTRIRFKDDSSYEEVNGIRKPRHLYVSMPTAQSTMKADEITPGRFRTIACGLFPAQV
KARNIISPVMGVIGFSFFVKDWMERIDDFLAARCPFLPEQKDPRDAALATNRAYFITRQLQVDESKVSDI
EDLIADARAESATIFADIATPHSVWVFACAPDRCPPTALYVAGMPELGAFFAILQDMRNTIMASKSVGTS
EEKLKKKSAFYQSYLRRTQSMGIQLDQKIIILYMSHWGREAVNHFHLGDDMDPELRELAQTLVDIKVREI
SNQEPLKL

Epitope Information

IEDB Linear Epitope