VIOLIN: Vaccine Investigation and Online Information Network

S segment

General Information

Protegen ID

491

Sequence Strain (Species/Organism)

Topografov virus

VO ID

VO_0011089

Taxonomy ID

83192

Other Database IDs

CDD:279218
GOA:Q9WMG3
InterPro: IPR002214
UniProtKB/TrEMBL: Q9WMG3

Molecule Role

Protective antigen

Molecule Role Annotation

To investigate the ability of recombinant N (rN, nucleocapsid proteins) from different hantaviruses to elicit cross-protection, we immunized bank voles with rN from Puumala (PUUV), Topografov (TOPV), Andes (ANDV), and Dobrava (DOBV) viruses and subsequently challenged them with PUUV. All animals immunized with PUUV and TOPV rN were completely protected (de Carvalho Nicacio et al., 2002).

Related Vaccines(s)

Topografov virus N protein vaccine

References

de Carvalho Nicacio et al., 2002: de Carvalho Nicacio C, Gonzalez Della Valle M, Padula P, Bjorling E, Plyusnin A, Lundkvist A. Cross-protection against challenge with Puumala virus after immunization with nucleocapsid proteins from different hantaviruses. Journal of virology. 2002 Jul; 76(13); 6669-77. [PubMed: 12050380].

Gene Information

Gene Name

S segment

Protein Information

Protein Name

N protein

NCBI Protein GI

4757106

Protein pI

5.8

Protein Weight

47447.65

Protein Length

487

Protein Note

Hantavirus nucleocapsid protein; pfam00846

Protein Sequence

>CAB42097.1 N protein [Topografov hantavirus]
MSNLKDIQDEITRYEQQLIVARQKLRDAEKTVEVDPDDVNKNTLQARRQTVSALEDKLADFKRQLADHVS
RQKMDEKPSDPTGIEPDDHLKERSSLRYGNVLDVNAIDIEEPSGQTADWFTIGVYIVSFTLPIILKALYM
LSTRGRQTVKENKGTRIRFKDDSSFEDVNGIRRPKHLYVSMPTAQSTMKAEELTPGRFRTIVCGLFPAQI
QARNIMSPVMGVIGFSFFVKDWPERIKNFLESKCPFIKPEVKPGAPAGEADFLSRNQIYFMRRQEVLEDN
HIPDIDKLLEYASSGDPTAPDSIESPYAPWVFACAPDRCPPTCIYIAGMAELGAFFSILQDMRNTIMASK
TVGTAEEKLKKKSSFYQSYLRRTQSMGIQLDQRIILLYMVEWGKEMVDHFHLGDDMDPDLRNLAQSLIDQ
KVKEISNQEPLKI

Epitope Information

IEDB Linear Epitope