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HTNVsSgp1

General Information
Protegen ID 493
Sequence Strain (Species/Organism) Hantaan orthohantavirus
VO ID VO_0011091
Taxonomy ID 1980471
Molecule Role Protective antigen
Molecule Role Annotation Passive transfer of spleen cells from mice immunized with rNP (HTNVsSgp1) conferred partial protection or prolongation of time to death from fatal Hantaan virus infection in suckling mice which were challenged with Hantaan virus at 40 LD50 (survival rate: 43%) or 4 LD50 (survival rate: 43%) (Yoshimatsu et al., 1993).
References
Yoshimatsu et al., 1993: Yoshimatsu K, Yoo YC, Yoshida R, Ishihara C, Azuma I, Arikawa J. Protective immunity of Hantaan virus nucleocapsid and envelope protein studied using baculovirus-expressed proteins. Archives of virology. 1993; 130(3-4); 365-376. [PubMed: 8517793].
Gene Information
Gene Name HTNVsSgp1
NCBI Gene ID 2943078
Genbank Accession M14626
Locus Tag HTNVsSgp1
Segment No segment S
Gene Starting Position 36
Gene Ending Position 1325
DNA Sequence 
>NC_005218.1:36-1325 Hantaan virus, complete genome
GATGGCAACTATGGAGGAATTACAGAGGGAAATCAATGCCCATGAGGGTCAATTAGTGATAGCCAGGCAG
AAGGTGAGGGATGCAGAAAAACAGTATGAAAAGGATCCAGATGAGTTGAACAAGAGAACATTAACTGACC
GAGAGGGCGTTGCAGTATCTATCCAGGCAAAAATTGATGAGTTAAAAAGGCAACTGGCAGATAGGATTGC
AACTGGGAAAAACCTTGGGAAGGAACAAGATCCAACAGGGGTGGAGCCTGGAGACCATCTGAAAGAGAGG
TCAATGCTCAGTTATGGTAATGTGCTGGATTTAAACCATTTGGATATTGATGAACCTACAGGACAGACAG
CAGACTGGCTGAGCATCATCGTCTATCTTACATCCTTTGTCGTCCCGATACTTCTGAAAGCTCTGTATAT
GTTGACAACAAGGGGGAGGCAAACTACCAAGGATAATAAAGGGACCCGGATTCGATTTAAGGATGATAGC
TCGTTCGAGGATGTTAACGGTATCCGGAAACCAAAACATCTTTACGTGTCCTTGCCAAATGCACAGTCAA
GCATGAAGGCAGAAGAGATTACACCTGGTAGATATAGAACAGCAGTCTGTGGGCTCTACCCTGCACAGAT
TAAGGCACGGCAGATGATCAGTCCAGTTATGAGTGTAATTGGTTTTCTAGCATTAGCAAAGGACTGGAGT
GATCGTATCGAACAATGGTTAATTGAACCTTGCAAGCTTCTTCCAGATACAGCAGCAGTTAGCCTCCTTG
GTGGTCCTGCAACAAACAGGGACTACTTACGGCAGCGGCAAGTGGCATTAGGCAATATGGAGACAAAGGA
GTCAAAGGCTATACGCCAGCATGCAGAAGCAGCTGGCTGTAGCATGATTGAAGATATTGAGTCACCATCA
TCAATATGGGTTTTTGCTGGAGCACCAGACCGTTGTCCACCAACATGTTTGTTTATAGCAGGTATTGCTG
AGCTTGGGGCATTTTTTTCCATCCTGCAGGACATGCGAAATACAATCATGGCATCTAAGACAGTTGGAAC
ATCTGAGGAGAAGCTACGGAAGAAATCATCATTTTATCAGTCCTACCTCAGAAGGACACAATCAATGGGG
ATACAACTAGGCCAGAGAATTATTGTGCTCTTCATGGTTGCCTGGGGAAAGGAGGCTGTGGACAACTTCC
ACTTAGGGGATGATATGGATCCTGAGCTAAGGACACTGGCACAGAGCTTGATTGATGTCAAAGTGAAGGA
AATCTCCAACCAAGAGCCTTTGAAACTCTA
Protein Information
Protein Name hypothetical protein
NCBI Protein GI 38371711
Protein Accession NP_941977
Protein pI 7.11
Protein Weight 45859.21
Protein Length 429
Protein Sequence 
>NP_941977.1 hypothetical protein [Hantaan orthohantavirus]
MATMEELQREINAHEGQLVIARQKVRDAEKQYEKDPDELNKRTLTDREGVAVSIQAKIDELKRQLADRIA
TGKNLGKEQDPTGVEPGDHLKERSMLSYGNVLDLNHLDIDEPTGQTADWLSIIVYLTSFVVPILLKALYM
LTTRGRQTTKDNKGTRIRFKDDSSFEDVNGIRKPKHLYVSLPNAQSSMKAEEITPGRYRTAVCGLYPAQI
KARQMISPVMSVIGFLALAKDWSDRIEQWLIEPCKLLPDTAAVSLLGGPATNRDYLRQRQVALGNMETKE
SKAIRQHAEAAGCSMIEDIESPSSIWVFAGAPDRCPPTCLFIAGIAELGAFFSILQDMRNTIMASKTVGT
SEEKLRKKSSFYQSYLRRTQSMGIQLGQRIIVLFMVAWGKEAVDNFHLGDDMDPELRTLAQSLIDVKVKE
ISNQEPLKL
Vaxign Prediction
Localization(Probability)
(Prob.=0)
Adhesin Probability 0.114
Trans-membrane Helices 0
Detailed Vaxign Results Vaxign Results
Epitope Information
IEDB Linear Epitope