VIOLIN: Vaccine Investigation and Online Information Network

HBVgp2 pre-S1/pre-S2/S

General Information

Protegen ID

497

Sequence Strain (Species/Organism)

Hepatitis B virus

VO ID

VO_0011095

Taxonomy ID

10407

Other Database IDs

CDD:109739

Molecule Role

Protective antigen

Molecule Role Annotation

Immunisation with a plasmid encoding the DHBV large (L) envelope protein (HBVgp2 pre-S1/pre-S2/S) induced a strong, specific, highly neutralising and long-lasting anti-preS humoral response in uninfected ducks. Importantly, maternal antibodies elicited by such DNA immunisation were vertically transmitted and protected progeny against viral challenge (Thermet et al., 2003).

Related Vaccines(s)

Hepatitis B DNA vaccine pCMV-S2.S encoding the HBV(ayw Strain) envelope protein.

References

Thermet et al., 2003: Thermet A, Rollier C, Zoulim F, Trepo C, Cova L. Progress in DNA vaccine for prophylaxis and therapy of hepatitis B. Vaccine. 2003; 21(7-8); 659-662. [PubMed: 12531335].

Gene Information

Gene Name

HBVgp2 pre-S1/pre-S2/S

NCBI Gene ID

944569

Genbank Accession

AF372622

Locus Tag

HBVgp2

Protein Information

Protein Name

large envelope protein

NCBI Protein GI

941241316

Protein Accession

YP_009173869

Protein pI

8.08

Protein Weight

41375.3

Protein Length

389

Protein Note

S gene product, put.surface antigen (AA 1-226)

Protein Sequence

>YP_009173869.1 large envelope protein [Hepatitis B virus]
MGQNLSTSNPLGFFPDHQLDPAFRANTANPDWDFNPNKDTWPDANKVGAGAFGLGFTPPHGGLLGWSPQA
QGILQTLPANPPPASTNRQSGRQPTPLSPPLRNTHPQAMQWNSTTFHQTLQDPRVRGLYFPAGGSSSGTV
NPVLTTASPLSSIFSRIGDPALNMENITSGFLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTV
CLGQNSQSPTSNHSPTSCPPTCPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTS
TGPCRTCMTTAQGTSMYPSCCCTKPSDGNCTCIPIPSSWAFGKFLWEWASARFSWLSLLVPFVQWFVGLS
PTVWLSVIWMMWYWGPSLYSILSPFLPLLPIFFCLWVYI

Epitope Information

IEDB Linear Epitope