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US6

General Information
Protegen ID 499
Sequence Strain (Species/Organism) Human alphaherpesvirus 2
VO ID VO_0011096
Taxonomy ID 10310
Molecule Role Protective antigen
Molecule Role Annotation The herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) gene was inserted into an intergenic site in the unique short region of the Oka VZV genome. Expression of gD2 in cells infected with the recombinant Oka strain VZV (ROka-gD2) was confirmed by antibody staining of fixed cells and by immunoblot analysis. Forty days after the third inoculation, guinea pigs were challenged intravaginally with HSV-2. Inoculation of guinea pigs with ROka-gD2 significantly reduced the severity of primary HSV-2 infection (P < 0.001) (Heineman et al., 1995).
References
Heineman et al., 1995: Heineman TC, Connelly BL, Bourne N, Stanberry LR, Cohen J. Immunization with recombinant varicella-zoster virus expressing herpes simplex virus type 2 glycoprotein D reduces the severity of genital herpes in guinea pigs. Journal of virology. 1995; 69(12); 8109-8113. [PubMed: 7494331].
Gene Information
Gene Name US6
NCBI Gene ID 1487358
Genbank Accession KX574902
Locus Tag HHV2p09
Gene Starting Position 141015
Gene Ending Position 143587
DNA Sequence 
>NC_001798.2:141015-143587 Human herpesvirus 2 strain HG52, complete genome
CATGGGGCGTTTGACCTCCGGCGTCGGGACGGCGGCCCTGCTAGTTGTCGCGGTGGGACTCCGCGTCGTC
TGCGCCAAATACGCCTTAGCAGACCCCTCGCTTAAGATGGCCGATCCCAATCGATTTCGCGGGAAGAACC
TTCCGGTTTTGGACCAGCTGACCGACCCCCCCGGGGTGAAGCGTGTTTACCACATTCAGCCGAGCCTGGA
GGACCCGTTCCAGCCCCCCAGCATCCCGATCACTGTGTACTACGCAGTGCTGGAACGTGCCTGCCGCAGC
GTGCTCCTACATGCCCCATCGGAGGCCCCCCAGATCGTGCGCGGGGCTTCGGACGAGGCCCGAAAGCACA
CGTACAACCTGACCATCGCCTGGTATCGCATGGGAGACAATTGCGCTATCCCCATCACGGTTATGGAATA
CACCGAGTGCCCCTACAACAAGTCGTTGGGGGTCTGCCCCATCCGAACGCAGCCCCGCTGGAGCTACTAT
GACAGCTTTAGCGCCGTCAGCGAGGATAACCTGGGATTCCTGATGCACGCCCCCGCCTTCGAGACCGCGG
GTACGTACCTGCGGCTAGTGAAGATAAACGACTGGACGGAGATCACACAATTTATCCTGGAGCACCGGGC
CCGCGCCTCCTGCAAGTACGCTCTCCCCCTGCGCATCCCCCCGGCAGCGTGCCTCACCTCGAAGGCCTAC
CAACAGGGCGTGACGGTCGACAGCATCGGGATGCTACCCCGCTTTATCCCCGAAAACCAGCGCACCGTCG
CCCTATACAGCTTAAAAATCGCCGGGTGGCACGGCCCCAAGCCCCCGTACACCAGCACCCTGCTGCCGCC
GGAGCTGTCCGACACCACCAACGCCACGCAACCCGAACTCGTTCCGGAAGACCCCGAGGACTCGGCCCTC
TTAGAGGATCCCGCCGGGACGGTGTCTTCGCAGATCCCCCCAAACTGGCACATCCCGTCGATCCAGGACG
TCGCGCCGCACCACGCCCCCGCCGCCCCCAGCAACCCGGGCCTGATCATCGGCGCGCTGGCCGGCAGTAC
CCTGGCGGTGCTGGTCATCGGCGGTATTGCGTTTTGGGTACGCCGCCGCGCTCAGATGGCCCCCAAGCGC
CTACGTCTCCCCCACATCCGGGATGACGACGCGCCCCCCTCGCACCAGCCATTGTTTTACTAGAGGAGTT
TCCCCGCTCCCGTGTACCTCTGGGCCCGTGTGGGAGGGTGGCTGGGGTATTTGGGTGGGACTTGGACTCC
GCATAAAGGGAGTCTCGAAGGAGGGAAACTAGGACAGTTCATAGGCCGGGAGCGTGGGGCGCGCACCGCT
GTCCCGACGATTAGCCACCGCGCCCACAGCCACCTCGACCCGTCCGATCCCGGTATGCCCGGCCGCTCGC
TGCAGGGCCTGGCGATCCTGGGCCTGTGGGTCTGCGCCACCGGCCTGGTCGTCCGCGGCCCCACGGTCAG
TCTGGTCTCAGACTCACTCGTGGATGCCGGGGCCGTGGGGCCCCAGGGCTTCGTGGAAGAGGACCTGCGT
GTTTTCGGGGAGCTTCATTTTGTGGGGGCCCAGGTCCCCCACACAAACTACTACGACGGCATCATCGAGC
TGTTTCACTACCCCCTGGGGAACCACTGCCCCCGCGTTGTACACGTGGTCACACTGACCGCATGCCCCCG
CCGCCCCGCCGTGGCGTTCACCTTGTGTCGCTCGACGCACCACGCCCACAGCCCCGCCTATCCGACCCTG
GAGCTGGGTCTGGCGCGGCAGCCGCTTCTGCGGGTTCGAACGGCAACGCGCGACTATGCCGGTCTGTATG
TCCTGCGCGTATGGGTCGGCAGCGCGACGAACGCCAGCCGGTTTGTTTTGGGGGTGGCGCTCTCTGCCAA
CGGGACGTTTGTGTATAACGGCTCGGACTACGGCTCCTGCGATCCGGCGCAGCTTCCCTTTTCGGCCCCG
CGCCTGGGACCCTCGAGCGTATACACCCCCGGAGCCTCCCGACCCACCCCTCCACGGACAACGACACCCC
CGTCCTCCCCCCGAGACCCGACCCCCGCCCCCGGGGACACAGGGACGCCCGCGCCCGCGAGCGGCGAGAT
AGCCCCGCCCAATTCCACGCGATCGGCCAGCGAATCGAGACACAGGCTAACCGTAGCCCAGGTAATCCAG
ATCGCCATACCGGCGTCCATCATCGCCTTTGTGTTTCTGGGCAGCTGTATCTGCTTCATCCATAGATGCC
AGCGCCGATACAGGCGCCCCCGCGGCCAGATTTACAACCCCGGGGGCGTTTCCTGCGCGGTCAACGAGGC
GGCCATGGCCCGCCTCGGAGCCGAGCTGCGATCCCACCCAAACACCCCCCCCAAACCCCGACGCCGTTCG
TCGTCGTCCACGACCATGCCTTCCCTAACGTCGATAGCTGAGGAATCGGAGCCAGGTCCAGTCGTGCTGC
TGTCCGTCAGTCCTCGGCCCCGCAGTGGCCCGACGGCCCCCCAAGAGGTCTAGGTCCAAGCGGGCCGTTC
GGCAGGCCCGCCCCACCGCCCCCATCGTGGTTATTTCCCCCCCCCCCCAATAA
Protein Information
Protein Name envelope glycoprotein D
NCBI Protein GI 820945218
Protein Accession YP_009137218
Protein pI 7.84
Protein Weight 40611.38
Protein Length 393
Protein Note gD family
Protein Sequence 
>YP_009137218.1 envelope glycoprotein D [Human alphaherpesvirus 2]
MGRLTSGVGTAALLVVAVGLRVVCAKYALADPSLKMADPNRFRGKNLPVLDQLTDPPGVKRVYHIQPSLE
DPFQPPSIPITVYYAVLERACRSVLLHAPSEAPQIVRGASDEARKHTYNLTIAWYRMGDNCAIPITVMEY
TECPYNKSLGVCPIRTQPRWSYYDSFSAVSEDNLGFLMHAPAFETAGTYLRLVKINDWTEITQFILEHRA
RASCKYALPLRIPPAACLTSKAYQQGVTVDSIGMLPRFIPENQRTVALYSLKIAGWHGPKPPYTSTLLPP
ELSDTTNATQPELVPEDPEDSALLEDPAGTVSSQIPPNWHIPSIQDVAPHHAPAAPSNPGLIIGALAGST
LAVLVIGGIAFWVRRRAQMAPKRLRLPHIRDDDAPPSHQPLFY
Epitope Information
IEDB Linear Epitope