VIOLIN: Vaccine Investigation and Online Information Network

E6 Type 16

General Information

Protegen ID

511

Sequence Strain (Species/Organism)

Human papillomavirus type 16

VO ID

VO_0011107

Taxonomy ID

333760

Molecule Role

Protective antigen

Molecule Role Annotation

C57BL/6 mice vaccinated with pNGVL4a-E6/opt are able to generate potent protective and therapeutic antitumor effects against challenge with E6-expressing tumor cell line, TC-1 of HPV (Lin et al., 2006).

Related Vaccines(s)

Human papillomavirus DNA vaccine CRT/E7 DNA , Human papillomavirus DNA vaccine hCRTE6E7L2 DNA encoding CRT linked to E6, E7 and L2 , Human papillomavirus DNA vaccine pNGVL4a-E6/opt

References

Lin et al., 2006: Lin CT, Tsai YC, He L, Calizo R, Chou HH, Chang TC, Soong YK, Hung CF, Lai CH. A DNA vaccine encoding a codon-optimized human papillomavirus type 16 E6 gene enhances CTL response and anti-tumor activity. Journal of biomedical science. 2006; 13(4); 481-488. [PubMed: 16649071].

Gene Information

Gene Name

E6 Type 16

NCBI Gene ID

1489078

Genbank Accession

AB663688

Locus Tag

HpV16gp1

Gene Starting Position

7124

Gene Ending Position

7600

DNA Sequence

>NC_001526.4:7124-7600 Human papillomavirus type 16, complete genome
TATGCACCAAAAGAGAACTGCAATGTTTCAGGACCCACAGGAGCGACCCAGAAAGTTACCACAGTTATGC
ACAGAGCTGCAAACAACTATACATGATATAATATTAGAATGTGTGTACTGCAAGCAACAGTTACTGCGAC
GTGAGGTATATGACTTTGCTTTTCGGGATTTATGCATAGTATATAGAGATGGGAATCCATATGCTGTATG
TGATAAATGTTTAAAGTTTTATTCTAAAATTAGTGAGTATAGACATTATTGTTATAGTTTGTATGGAACA
ACATTAGAACAGCAATACAACAAACCGTTGTGTGATTTGTTAATTAGGTGTATTAACTGTCAAAAGCCAC
TGTGTCCTGAAGAAAAGCAAAGACATCTGGACAAAAAGCAAAGATTCCATAATATAAGGGGTCGGTGGAC
CGGTCGATGTATGTCTTGTTGCAGATCATCAAGAACACGTAGAGAAACCCAGCTGTA

Protein Information

Protein Name

transforming protein E6

NCBI Protein GI

9627104

Protein Accession

NP_041325

Protein pI

8.97

Protein Weight

18789.29

Protein Length

158

Protein Note

E6 ORF from 65 to 559; putative

Protein Sequence

>NP_041325.1 transforming protein E6 [Human papillomavirus type 16]
MHQKRTAMFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVC
DKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWT
GRCMSCCRSSRTRRETQL

Vaxign Prediction

Localization(Probability)

(Prob.=0)

Adhesin Probability

0.114

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope