VIOLIN: Vaccine Investigation and Online Information Network

HA

General Information

Protegen ID

516

Sequence Strain (Species/Organism)

Equine influenza virus H3N8

VO ID

VO_0011112

Taxonomy ID

907195

Other Database IDs

CDD:278910

Molecule Role

Protective antigen

Molecule Role Annotation

Skin and mucosal vaccination provided complete protection from clinical signs of infection with ponies subjected to a challenge infection of Equine influenza virus, while skin vaccination provided partial protection; DNA vaccination provided partial protection from viral shedding (Lunn et al., 1999).

Related Vaccines(s)

Influenza virus DNA vaccine encoding HA of Equine influenza virus H3N8

References

Lunn et al., 1999: Lunn DP, Soboll G, Schram BR, Quass J, McGregor MW, Drape RJ, Macklin MD, McCabe DE, Swain WF, Olsen CW. Antibody responses to DNA vaccination of horses using the influenza virus hemagglutinin gene. Vaccine. 1999; 17(18); 2245-2258. [PubMed: 10403592].

Gene Information

Gene Name

Protein Information

Protein Name

hemagglutinin

NCBI Protein GI

404517

Protein pI

7.4

Protein Weight

61514.34

Protein Length

648

Protein Note

Protein Sequence

>AAB27733.1 hemagglutinin [Influenza A virus (A/equine/Taby/1991(H3N8))]
MKTTIILILLTHWVYSQNPTSGNNTATLCLGHHAVANGTLVKTITDDQIEVTNATELVQSISIGKICNNS
YRVLDGRNCTLIDAMLGDPHCDDFQYENWDLFIERSSAFSNCYPYDIPDHASLRSIVASSGTLEFTAEGF
TWTGVTQNGGSGACKRGSADSFFSRLNWLTKSGNSYPILNVTMPNNKNFDKLYIWGIHHPSSNKEQTKLY
IQESGRVTVSTERSQQTVIPNIGSRPWVRGQSGRISIYWTIVKPGDILMINSNGNLVAPRGYFKLRTGES
SVMRSDALIGTCVSECITPNGSIPNDKPFQNVNKVTYGKCPKYIRQNTLKLATGMRNVPEKQIRGIFGAI
AGFIENGWEGMVDGWYGFRYQNSEGTGQAADLKSTQAAIDQINGKLNRVIERTNEKFHQIEKEFSEVEGR
IQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDAEMNKLFEKTRRQLRENAEDMGGGCFKIYHKCDN
ACIGSIRNGTYDHYIYRDEALNNRFQIKGVELKSGYKDWILWISFAISCLLICVVLLGFIMWACQKGNIR
CNICI

Vaxign Prediction

Localization(Probability)

(Prob.=0)

Adhesin Probability

0.404

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope