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HA from Influenza A virus (A/WSN/1933(H1N1))

General Information
Protegen ID 518
Sequence Strain (Species/Organism) Influenza A virus (A/WSN/1933(H1N1))
VO ID VO_0011113
Taxonomy ID 382835
Other Database IDs CDD:278910
Molecule Role Protective antigen
Molecule Role Annotation A nonpathogenic vector of the cytoplasmic domain of the VSV G protein and expressing influenza virus HA (derived from Influenza A virus (A/WSN/1933(H1N1))) provides complete protection from lethal influenza virus challenge after intranasal administration. A second vector with VSV G deleted and expressing HA (DeltaG-HA) is also protective and nonpathogenic and has the advantage of not inducing neutralizing antibodies to the vector itself (Roberts et al., 1999).
Related Vaccines(s) Recombinant vesicular stomatitis virus encoding HA from Influenza A virus (A/WSN/1933(H1N1))
References
Roberts et al., 1999: Roberts A, Buonocore L, Price R, Forman J, Rose JK. Attenuated vesicular stomatitis viruses as vaccine vectors. Journal of virology. 1999; 73(5); 3723-3732. [PubMed: 10196265].
Gene Information
Gene Name HA from Influenza A virus (A/WSN/1933(H1N1))
Protein Information
Protein Name hemagglutinin precursor
NCBI Protein GI 324200
Protein pI 7.02
Protein Weight 61355.76
Protein Length 650
Protein Note signal peptide
Protein Sequence 
>AAA43209.1 hemagglutinin precursor [Influenza A virus (A/WSN/1933(H1N1))]
MKAKLLVLLYAFVATDADTICIGYHANNSTDTVDTIFEKNVAVTHSVNLLEDRHNGKLCKLKGIAPLQLG
KCNITGWLLGNPECDSLLPARSWSYIVETPNSENGACYPGDFIDYEELREQLSSVSSLERFEIFPKESSW
PNHTFNGVTVSCSHRGKSSFYRNLLWLTKKGDSYPKLTNSYVNNKGKEVLVLWGVHHPSSSDEQQSLYSN
GNAYVSVASSNYNRRFTPEIAARPKVKDQHGRMNYYWTLLEPGDTIIFEATGNLIAPWYAFALSRGFESG
IITSNASMHECNTKCQTPQGSINSNLPFQNIHPVTIGECPKYVRSTKLRMVTGLRNIPSIQYRGLFGAIA
GFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMNTQFTAVGKEFNNLEKRM
ENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDLNVKNLYEKVKSQLKNNAKEIGNGCFEFYHKCDNE
CMESVRNGTYDYPKYSEESKLNREKIDGVKLESMGVYQILAIYSTVASSLVLLVSLGAISFWMCSNGSLQ
CRICI
Vaxign Prediction
Localization(Probability)
(Prob.=0)
Adhesin Probability 0.438
Trans-membrane Helices 1
Detailed Vaxign Results Vaxign Results
Epitope Information
IEDB Linear Epitope