VIOLIN: Vaccine Investigation and Online Information Network

HA

General Information

Protegen ID

522

Sequence Strain (Species/Organism)

Influenza B virus (Strain B/England/222/82)

VO ID

VO_0011117

Taxonomy ID

11527

Other Database IDs

CDD:278910

Molecule Role

Protective antigen

Molecule Role Annotation

Immunization and challenge experiments in mice indicated that even though vaccination with the recombinant HA vaccinia viruses derived from Influenza B virus (Strain B/England/222/82) induced different levels of cross-reactive neutralizing antibodies, mice vaccinated with either recombinant vaccinia virus were protected from infection with either subpopulation of influenza virus (Rota et al., 1987).

Related Vaccines(s)

Recombinant vaccinia virus encoding HA from Influenza B virus (Strain B/England/222/82)

References

Rota et al., 1987: Rota PA, Shaw MW, Kendal AP. Comparison of the immune response to variant influenza type B hemagglutinins expressed in vaccinia virus. Virology. 1987; 161(2); 269-275. [PubMed: 3318092].

Gene Information

Gene Name

Protein Information

Protein Name

Hemagglutinin

NCBI Protein GI

122955

Protein pI

8.36

Protein Weight

62677.29

Protein Length

761

Protein Note

{ECO:0000255|HAMAP-Rule:MF_04072}.

Protein Sequence

>sp|P10757.1|HEMA_INBEN RecName: Full=Hemagglutinin; Contains: RecName: Full=Hemagglutinin HA1 chain; Contains: RecName: Full=Hemagglutinin HA2 chain; Flags: Precursor
MKAIIVLLMVVTSNADRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTPTKSHFANLKGTKTRGKLCP
NCLNCTDLDVALARPKCMGTIPSAKASILHEVKPVTSGCFPIMHDRTKIRQLPNLLRGYENIKLSTRNVI
NAERAPGGPYIIGTSGSCPNVTNGNGFFATMAWAVPKDNKTATNPLTVEVPYICTKGEDQITVWGFHSDN
AIQMVKLYGDSKPQKFTSSANGVTTHYVSQIGGFPNQTEDGGLPQSGRIVVDYMVQKPGKTGTIVYQRGV
LLPQKVWCASGRSKVIKGSLPLIGEADCLHEKYGGLNKSKPYYTGEHAKAIGNCPIWVKTPLKLANGTKY
RPPAKLLKERGFFGAIAGFLEGGWEGMIAGWHGYTSHGAHGVAVAADLKSTQEAINKITKNLNSLSELEV
KNLQRLSGAMDELHNEILELDEKVDDLRADTISSQIELAVLLSNEGIINSEDEHLLALERKLKKMLGPSA
VDIGNGCFETKHKCNQTCLDRIAAGTFNAGEFSLPTFDSLNITAASLNDDGLDNHTILLYYSTAASSLAV
TLMIAIFIVYMVSRDNVSCSICL

Vaxign Prediction

Localization(Probability)

(Prob.=0)

Adhesin Probability

0.446

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope