VIOLIN: Vaccine Investigation and Online Information Network

HA

General Information

Protegen ID

523

Sequence Strain (Species/Organism)

Influenza A virus (A/duck/Badung-Bali/05/2005(H5N1))

VO ID

VO_0011118

Taxonomy ID

1661658

Other Database IDs

CDD:278910

Molecule Role

Protective antigen

Molecule Role Annotation

Mice vaccinated with a recombinant VLP vaccine from both influenza A H5N1 clade 1 and clade 2 isolates (Influenza A virus (A/duck/Badung-Bali/05/2005(H5N1))) with pandemic potential were protected against challenge with lethal reassortant viruses expressing the H5N1 HA and NA, regardless if the H5N1 clade was homologous or heterologous to the vaccine (Bright et al., 2008).

References

Bright et al., 2008: Bright RA, Carter DM, Crevar CJ, Toapanta FR, Steckbeck JD, Cole KS, Kumar NM, Pushko P, Smith G, Tumpey TM, Ross TM. Cross-clade protective immune responses to influenza viruses with H5N1 HA and NA elicited by an influenza virus-like particle. PloS one. 2008; 3(1); e1501. [PubMed: 18231588].

Gene Information

Gene Name

Protein Information

Protein Name

hemagglutinin

NCBI Protein GI

190344179

Protein pI

6.67

Protein Weight

58202.54

Protein Length

623

Protein Note

subtype: H5N1

Protein Sequence

>ABG20467.2 hemagglutinin, partial [Influenza A virus (A/duck/Badung/05/2005(H5N1))]
DQICIGYHANNSTEQVDTIMEKNVTVTHAKDILEKTHNGKLCDLDGVKPLILRDCSVAGWLLGNPMCDEF
TNVPEWSYIVEKANPANDLCYPGNFNDYEELKHLLSRINHFEKIQIIPKSSWSDHEASLGVSSACPYQGQ
SSFFRNVVWLIKKNSAYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTRLYQNPTTYISVGTSTLNQRLV
PKIATRSKVNGQSGRMEFFWTIFKPNDAINFESNGNFIAPEYAYKIVKKGDSAIMKSELEYGNCNTECQT
PMGAINSSMPFHNIHPLTIRECPKYMKSSRLVLATGLRNSPQGERRRKKRGLFGAIAGFIEGGWQGMVDG
WYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLERRIENLNKKMEDGFLD
VWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLKDNAKELGNGCFEFYHKCDNECMESIRNGTYNYP
QYSEEARLKREEISGVKLESIGTYQILSIYSTVASSLAL

Epitope Information

IEDB Linear Epitope