VIOLIN: Vaccine Investigation and Online Information Network

HA

General Information

Protegen ID

535

Sequence Strain (Species/Organism)

Influenza B virus (B/Ibaraki/2/85)

VO ID

VO_0011128

Taxonomy ID

107411

Other Database IDs

CDD:278910

Molecule Role

Protective antigen

Molecule Role Annotation

Protection against a lethal influenza B virus infection was examined in BALB/c mice immunized with plasmid DNAs encoding hemagglutinin (HA), neuraminidase (NA and NB) and nucleoprotein (NP) from the B/Ibaraki/2/85 virus. Both HA and NA DNAs conferred complete protection against the lethal challenge in all the tested mouse strains (Chen et al., 2001).

Related Vaccines(s)

Influenza virus DNA vaccine encoding HA from Influenza B virus (B/Ibaraki/2/85)

References

Chen et al., 2001: Chen Z, Kadowaki S, Hagiwara Y, Yoshikawa T, Sata T, Kurata T, Tamura S. Protection against influenza B virus infection by immunization with DNA vaccines. Vaccine. 2001; 19(11-12); 1446-1455. [PubMed: 11163667].

Gene Information

Gene Name

Protein Information

Protein Name

Hemagglutinin

NCBI Protein GI

122959

Protein pI

9.88

Protein Weight

37274.43

Protein Length

454

Protein Note

Hemagglutinin HA1 chain. /FTId=PRO_0000039110.

Protein Sequence

>sp|P18878.1|HEMA_INBIB RecName: Full=Hemagglutinin; Contains: RecName: Full=Hemagglutinin HA1 chain
DRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTPTKSHFANLKGTKTRGKLCPKCLNCTDLDVALGRP
KCMGTIPSAKASILHEVKPVTSGCFPIMHDRTKIRQLPNLLRGYENIRLSTHNVINAETAPGGPYIVGTS
GSCPNVTNGNGFFATMAWAVPKNNNNKTATNPLTVEVPFICTEGEDQITVWGFHSDDETQMVKLYGDSKP
QKFTSSANGVTTHYVSQIGGFPNQAEDGGLPQSGRIVVDHMVQKSGKTGTITYQRGILLPQKVSCPSGRS
KVIKGSFPLIGEADCLHEKYGALNKSKPYYTGAHAKAIGNCPIWVKTPLKLANGTKYRPPAKLLKER

Vaxign Prediction

Localization(Probability)

(Prob.=0)

Adhesin Probability

0.699

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope