VIOLIN: Vaccine Investigation and Online Information Network

NA

General Information

Protegen ID

536

Sequence Strain (Species/Organism)

Influenza B virus (B/Ibaraki/2/85)

VO ID

VO_0011129

Taxonomy ID

107411

Other Database IDs

CDD:278493

Molecule Role

Protective antigen

Molecule Role Annotation

Protection against a lethal influenza B virus infection was examined in BALB/c mice immunized with plasmid DNAs encoding hemagglutinin (HA), neuraminidase (NA and NB) and nucleoprotein (NP) from the B/Ibaraki/2/85 virus. Both HA and NA DNAs conferred complete protection against the lethal challenge in all the tested mouse strains (Chen et al., 2001).

Related Vaccines(s)

Influenza virus DNA vaccine encoding NA from Influenza B virus (B/Ibaraki/2/85)

References

Chen et al., 2001: Chen Z, Kadowaki S, Hagiwara Y, Yoshikawa T, Sata T, Kurata T, Tamura S. Protection against influenza B virus infection by immunization with DNA vaccines. Vaccine. 2001; 19(11-12); 1446-1455. [PubMed: 11163667].

Gene Information

Gene Name

Protein Information

Protein Name

NA glycoprotein

NCBI Protein GI

53829726

Protein pI

7.54

Protein Weight

50164.23

Protein Length

538

Protein Note

Neuraminidase; pfam00064

Protein Sequence

>AAU94751.1 NA glycoprotein [Influenza B virus (B/Ibaraki/2/85)]
MLPSTIQTLTLFLTSGGVLLSLYVSASLSYLLYSDILLKFSPKITAPTMTLDCANASNVQAVNRSATKEM
TFLLPEPEWTYPRLSCQGSTFQKALLISPHRFGEARGNSAPLIIREPFIACGPKECKHFALTHYAAQPGG
YYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSNALIKIKYGEAYT
DTYHSYANNILRTQESACNCIGGDCYLMITDGSASGISKCRFLKIREGRIIKEIFPTGRVEHTEECTCGF
ASNKTIECACRDNNYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGRGGIKGG
FVHQRMASKIGRWYSRTMSKTERMGMELYVKYDGDPWTDSDALAPSGVMVSMKEPGWYSFGFEIKDKKCD
VPCIGIEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL

Epitope Information

IEDB Linear Epitope