VIOLIN: Vaccine Investigation and Online Information Network

HA

General Information

Protegen ID

537

Sequence Strain (Species/Organism)

Influenza A virus (A/Indonesia/CDC669/2006(H5N1))

VO ID

VO_0011130

Taxonomy ID

400828

Other Database IDs

CDD:278910

Molecule Role

Protective antigen

Molecule Role Annotation

Viral challenge studies showed that live BacHA derived from Influenza A virus (A/Indonesia/CDC669/2006(H5N1)) was able to provide 100% protection against 5 50% mouse lethal doses (MLD(50)) of homologous (clade 2.1) and heterologous (clade 1) H5N1 (Prabakaran et al., 2010).

Related Vaccines(s)

BacHA derived from Influenza A virus (A/Indonesia/CDC669/2006(H5N1))

References

Prabakaran et al., 2010: Prabakaran M, Madhan S, Prabhu N, Qiang J, Kwang J. Gastrointestinal delivery of baculovirus displaying influenza virus hemagglutinin protects mice against heterologous H5N1 infection. Journal of virology. 2010; 84(7); 3201-3209. [PubMed: 20071572].

Gene Information

Gene Name

Protein Information

Protein Name

hemagglutinin

NCBI Protein GI

113497156

Protein pI

6.77

Protein Weight

62447.44

Protein Length

656

Protein Note

Haemagglutinin; pfam00509

Protein Sequence

>ABI36428.1 hemagglutinin [Influenza A virus (A/Indonesia/CDC669/2006(H5N1))]
MEKIVLLLAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLDGVKPLILRD
CSVAGWLLGNPMCDEFINVPEWSYIVEKANPTNDLCYPGSFNDYEELKHLLSRINHFEKIQIIPKSSWSD
HEASSGVSSACPYLGSPSFFRNVVWLIKKNSTYPTIKKSYNNTNQEDLLVLWGIHHPNDAAEQTRLYQNP
TTYISIGTSTLNQRLVPKIATRSKVNGQSGRMEFFWAILKPNDAINFESNGNFIAPEYAYKIVKKGDSAI
MKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRESRRKKRGLFG
AIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLE
RRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKC
DNECMESIRNGTYNYPQYSEEARLKREEISGVKLESIGTYQILSIYSTVASSLALAIMIAGLSLWMCSNG
SLQCRICI

Vaxign Prediction

Localization(Probability)

(Prob.=0)

Adhesin Probability

0.220

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope