VIOLIN: Vaccine Investigation and Online Information Network

HA

General Information

Protegen ID

539

Sequence Strain (Species/Organism)

Influenza A virus (A/Hawaii/01/1991(H3N2))

VO ID

VO_0011132

Taxonomy ID

387158

Other Database IDs

CDD:278910

Molecule Role

Protective antigen

Molecule Role Annotation

A DNA vaccine encoding HA (from Influenza A virus (A/Hawaii/01/1991(H3N2))), NP and M1 (from a 1989 strain) protected ferrets better against challenge with the antigenic drift variant A/Georgia/03/93 than did the inactivated vaccine from the 1992-93 influenza season. Researchers report that the same DNA vaccine protected ferrets against a second, further divergent, drift variant (A/Johannesburg/33/94) (Donnelly et al., 1997).

References

Donnelly et al., 1997: Donnelly JJ, Friedman A, Ulmer JB, Liu MA. Further protection against antigenic drift of influenza virus in a ferret model by DNA vaccination. Vaccine. 1997; 15(8); 865-868. [PubMed: 9234535].

Gene Information

Gene Name

Protein Information

Protein Name

haemagglutinin

NCBI Protein GI

110313990

Protein pI

9.43

Protein Weight

35361.77

Protein Length

416

Protein Note

egg isolate

Protein Sequence

>ABG66978.1 haemagglutinin, partial [Influenza A virus (A/Hawaii/01/1991(H3N2))]
QKLPGNDNSTATLCLGHHAVPNGTLVKTITNDQIEVTNATELVQSSSTGRICDSPHRILDGKNCTLIDAL
LGDPHCDGFQNKEWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFINEDFNWTGVAQSGESYACK
RGSVKSFFSRLNWLHKSEYKYPALNVTMPNNGKFDKLYIWGVHHPSTDREQTSLYVRASGRVTVSTKRSQ
QTVIPNIGSRPWVRGLSSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRTGKSSIMRSDAPIGTCSSE
CITPNGSIPNDKPFQNVNRITYGACPRYVKQNTLKLATGMRNVPEKQTR

Vaxign Prediction

Localization(Probability)

(Prob.=0)

Adhesin Probability

0.549

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope