VIOLIN: Vaccine Investigation and Online Information Network

HA

General Information

Protegen ID

540

Sequence Strain (Species/Organism)

Influenza A virus (A/chicken/Henan/12/2004(H5N1))

VO ID

VO_0011133

Taxonomy ID

319102

Other Database IDs

CDD:278910

Molecule Role

Protective antigen

Molecule Role Annotation

Plasmids carrying the HA, NA, NP, M1, and M2 genes, respectively, of the avian influenza virus (AIV) A/Chicken/Henan/12/2004(H5N1) strain were administered to mice, and the mice were challenged with the homologous virus later. The mice immunized with HA plasmid once and the NA plasmid twice survived 100% (Chen et al., 2009).

Related Vaccines(s)

Influenza virus DNA vaccine encoding HA from Influenza A virus (A/chicken/Henan/12/2004(H5N1))

References

Chen et al., 2009: Chen Q, Kuang H, Wang H, Fang F, Yang Z, Zhang Z, Zhang X, Chen Z. Comparing the ability of a series of viral protein-expressing plasmid DNAs to protect against H5N1 influenza virus. Virus genes. 2009; 38(1); 30-38. [PubMed: 19067149].

Gene Information

Gene Name

Protein Information

Protein Name

hemagglutinin

NCBI Protein GI

61698018

Protein pI

7.19

Protein Weight

61969.572

Protein Length

656

Protein Note

Haemagglutinin; pfam00509

Protein Sequence

>AAX53506.1 hemagglutinin [Influenza A virus (A/chicken/Henan/12/2004(H5N1))]
MEKIVLLLAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLDGVKPLILRD
CSVAGWLLGNPMCDEFINVPEWSYIVEKASPANGLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSN
HEASSGVSSACPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTRLYQNP
TTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSAI
MKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRERRRKKRGLFG
AIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLE
RRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKC
DNECMESVRNGTYDYPQYSEEARLKREEISGVKLESIGTYQILSIYSTVASSLALAIMVAGLSLWMCSNG
SLQCRICI

Epitope Information

IEDB Linear Epitope