VIOLIN: Vaccine Investigation and Online Information Network

NA

General Information

Protegen ID

542

Sequence Strain (Species/Organism)

Influenza A virus (A/chicken/Henan/12/2004(H5N1))

VO ID

VO_0011135

Taxonomy ID

319102

Other Database IDs

CDD:271235

Molecule Role

Protective antigen

Molecule Role Annotation

Plasmids carrying the HA, NA, NP, M1, and M2 genes, respectively, of the avian influenza virus (AIV) A/Chicken/Henan/12/2004(H5N1) strain were administered to mice, and the mice were challenged with the homologous virus later. The mice immunized with HA plasmid once and the NA plasmid twice survived 100% (Chen et al., 2009).

Related Vaccines(s)

Influenza virus DNA vaccine encoding NA from Influenza A virus (A/chicken/Henan/12/2004(H5N1))

References

Chen et al., 2009: Chen Q, Kuang H, Wang H, Fang F, Yang Z, Zhang Z, Zhang X, Chen Z. Comparing the ability of a series of viral protein-expressing plasmid DNAs to protect against H5N1 influenza virus. Virus genes. 2009; 38(1); 30-38. [PubMed: 19067149].

Gene Information

Gene Name

Protein Information

Protein Name

neuraminidase

NCBI Protein GI

61698053

3D structure: PDB ID

2HTY

Protein pI

6.62

Protein Weight

46889.862

Protein Length

535

Protein Note

Sialidase or neuraminidase (EC 3.2.1.18) of Influenza viruses A and B; cd15483

Protein Sequence

>AAX53527.1 neuraminidase [Influenza A virus (A/chicken/Henan/12/2004(H5N1))]
MNPNQKIITIGSICMVIGIVSLMLQIGNMISIWVSHSIQTGNQHQAEPISNTNFLTEKAVASVTLAGNSS
LCPISGWAVHSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPHRTLMS
CPVGEAPSPYNSRFESVAWSASACHDGTSWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESE
CACVNGSCFTVMTDGPSNGQASYKIFKMEKGKVVKSVELEAPNYHYEECSCYPDAGEITCVCRDNWHGSN
RPWVSFNQNLEYQIGYICSGVFGDNPRPNDGTGSCGPVSPNGAYGVKGFSFKYGNGVWIGRTKSTNSRSG
FEMIWDPNGWTGTDSSFSVKQDIVAITDWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKESTIWTSG
SSISFCGVNSDTVGWSWPDGAELPFTIDK

Vaxign Prediction

Localization(Probability)

(Prob.=0)

Adhesin Probability

0.763

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope