VIOLIN: Vaccine Investigation and Online Information Network

HA

General Information

Protegen ID

546

Sequence Strain (Species/Organism)

Influenza A virus (A/chicken/Guangdong/02/2007(H9N2))

VO ID

VO_0011139

Taxonomy ID

563925

Other Database IDs

CDD:278910

Molecule Role

Protective antigen

Molecule Role Annotation

Using reverse genetics, we constructed a recombinant NDV expressing an H9 AIV hemagglutinin (HA) from an H9N2 field isolate, A/Chicken/ Shandong/2/2007. When tested, 90% of chickens were protected from clinical disease, mortality, and virus shedding against challenge with homologous H9N2 AIV (Ge et al., 2010).

References

Ge et al., 2010: Ge J, Tian G, Zeng X, Jiang Y, Chen H, Bua Z. Generation and evaluation of a Newcastle disease virus-based H9 avian influenza live vaccine. Avian diseases. 2010; 54(1 Suppl); 294-296. [PubMed: 20521648].

Gene Information

Gene Name

Protein Information

Protein Name

hemagglutinin

NCBI Protein GI

206812650

Protein pI

7.03

Protein Weight

60115.68

Protein Length

651

Protein Note

Haemagglutinin; pfam00509

Protein Sequence

>ACI22603.1 hemagglutinin [Influenza A virus (A/chicken/Guangdong/02/2007(H9N2))]
METVSIITMLLVVTVSNADKICIGYQSTNSTETVDTLTENNVPVTHAKELLHTEHNGMLCATTLGNPLIL
DTCTIEGLIYGNPSCDLLLGGREWSYIVERPSAVNGLCYPGNVENLEELRSLFSSASSYQRIQIFPDTIW
NVSYSGTSKACSDSFYRSMRWLTQKNNAYPIQDAQYTNNREKNILFMWGINHPPTDTVQTNLYTRTDTTT
SVATEEINRTFKPLIGPRPLVNGLQGRIDYYWSVLKPGQTLRIRSNGNLIAPWYGHILSGESHGRILKTD
LKRGSCTVQCQTEKGGLNTTLPFQNVSKYAFGNCSKYVGVKSLKLAVGLRSVPSRSSRGLFGAIAGFIEG
GWSGLVAGWYGFQHSNDQGVGMAADKDSTQKAIDKITSKVNNIVDKMNKQYEIIDHEFSEVETRLNMINN
KIDDQIQDIWAYNAELLVLLENQKTLDEHDANVNNLYNKVKRALGSNAVEDGKGCFELYHKCDDQCMETI
RNGTYNRRKYQEESKLERQRIEGVKLESEGTYKILTIYSTVASSLVVAMGFAAFLFWAMSNGSCRCNICI

Vaxign Prediction

Localization(Probability)

(Prob.=0)

Adhesin Probability

0.382

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope