VIOLIN: Vaccine Investigation and Online Information Network

HA

General Information

Protegen ID

549

Sequence Strain (Species/Organism)

Influenza A virus (A/turkey/Ireland/1378/1983(H5N8))

VO ID

VO_0011141

Taxonomy ID

380285

Other Database IDs

CDD:278910

Molecule Role

Protective antigen

Molecule Role Annotation

All specific-pathogen-free chickens immunized with (vFP89) expressing the native hemagglutinin (HA) gene from H5N8 A/turkey/ Ireland/1378/83 were clinically protected from HPAI challenge (Bublot et al., 2010).

Related Vaccines(s)

FP-AI-H5(H5N1) , Influenza virus DNA vaccine pCMVH5HA , Influenza virus DNA vaccine pÎ²actinH7HA , vFP89-H5 , vFP89-HA (H5N1 HPAI virus)

References

Bublot et al., 2010: Bublot M, Manvell RJ, Shell W, Brown IH. High level of protection induced by two fowlpox vector vaccines against a highly pathogenic avian influenza H5N1 challenge in specific-pathogen-free chickens. Avian diseases. 2010; 54(1 Suppl); 257-261. [PubMed: 20521642].

Gene Information

Gene Name

Protein Information

Protein Name

hemagglutinin

NCBI Protein GI

115279333

Protein pI

7.46

Protein Weight

62067.27

Protein Length

657

Protein Note

Haemagglutinin; pfam00509

Protein Sequence

>ABI85117.1 hemagglutinin [Influenza A virus (A/turkey/Ireland/1378/1983(H5N8))]
MEKIVLLFAIVSLVRSDQICIGYHANNSTKQVDTIMEKNVTVTHAQDILEKTHNGKLCSLNGVKPLILRD
CSVAGWLLGNPMCDEFLNVPEWSYIVEKDNPVNGLCYPGDFNDYEELKHLLSCTKHFEKIRIIPRDSWPN
HEASLGVSSACPYNGRSSFFRNVVWLIKKNNAYPTIKRSYSNTNKEDLLILWGIHHPNDAAEQTKLYQNP
TTYVSVGTSTLNQRSIPKIATRPELNGQSGRMEFFWTILKPSDTINFESNGNFIAPEYAYKIVKKGDSAI
MKSGLEYGNCNTKCQTPIGAINSSMPLHNIHPLTIGECPKYVKSDRLVLATGLRNTPQRKRKKRGLFGAI
AGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQRAIDGITNKVNSIIDKMNTQFEAVGKEFNNLERR
IENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDANVKSLYDKVRLQLKDNARELGNGCFEFYHKCDN
ECMESIRNGTYNYPQYSEEARLNREEISGVKLESMGIYQILSIYSTVASSLALAIMIAGLSFWMCSNGSL
QCRICI

Epitope Information

IEDB Linear Epitope