VIOLIN: Vaccine Investigation and Online Information Network

HA

General Information

Protegen ID

550

Sequence Strain (Species/Organism)

Influenza A virus (A/chicken/Indonesia/7/2003(H5N1))

VO ID

VO_0011142

Taxonomy ID

430432

Other Database IDs

CDD:278910

Molecule Role

Protective antigen

Molecule Role Annotation

All specific-pathogen-free chickens immunized with (vFP2211) expressing a modified synthetic HA gene from H5N1 A/chicken/Indonesia/7/2003 were clinically protected from HPAI challenge (Bublot et al., 2010).

Related Vaccines(s)

FP-AI-H5(H5N1) , Trovac-AI-H5

References

Bublot et al., 2010: Bublot M, Manvell RJ, Shell W, Brown IH. High level of protection induced by two fowlpox vector vaccines against a highly pathogenic avian influenza H5N1 challenge in specific-pathogen-free chickens. Avian diseases. 2010; 54(1 Suppl); 257-261. [PubMed: 20521642].

Gene Information

Gene Name

Protein Information

Protein Name

hemagglutinin

NCBI Protein GI

129282887

Protein pI

7.16

Protein Weight

62036.07

Protein Length

659

Protein Note

Haemagglutinin; pfam00509

Protein Sequence

>ABO30346.1 hemagglutinin [Influenza A virus (A/chicken/Indonesia/7/2003(H5N1))]
MEKIVLLLAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLDGVKPLILRD
CSVAGWLLGNPMCDEFINVPEWSYIVEKANPANDLCYPGNLNDYEELKHLLSRINHFEKIQIIPKSSWSD
HEASSGVSSACPYQGKSSFFRNVVWLIKKNSAYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTRLYQNP
TTYISVGTSTLNQRLVPKIAIRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSAI
MKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRERRRKKRGLFG
AIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLE
RRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKC
DNECMESIRNGTYNYPQYSEEARLKREEISGVKLESIGTYQILSIYSTVASSLALAIMMAGLSLWMCSNG
SLQCRICI

Vaxign Prediction

Localization(Probability)

(Prob.=0)

Adhesin Probability

0.210

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope