VIOLIN: Vaccine Investigation and Online Information Network

HA

General Information

Protegen ID

551

Sequence Strain (Species/Organism)

Influenza A virus (A/Hatay/2004/(H5N1))

VO ID

VO_0011143

Taxonomy ID

303316

Other Database IDs

CDD:278910
GOA:Q5QQ29
InterPro: IPR000149
InterPro: IPR001364
InterPro: IPR008980
InterPro: IPR013827
InterPro: IPR013828
InterPro: IPR013829
UniProtKB/TrEMBL: Q5QQ29

Molecule Role

Protective antigen

Molecule Role Annotation

A neutralizing monoclonal antibody (mAb) 9F4 against the hemagglutinin (HA) of the influenza A/chicken/hatay/2004 H5N1 virus was generated. MAb 9F4 was found to be protective, both prophylactically and therapeutically, against lethal viral challenge of mice (Oh et al., 2010).

References

Oh et al., 2010: Oh HL, Akerstrom S, Shen S, Bereczky S, Karlberg H, KlingstrÃ¶m J, Lal SK, Mirazimi A, Tan YJ. An antibody against a novel and conserved epitope in the HA1 subunit neutralizes numerous H5N1 influenza viruses. Journal of virology. 2010; ; . [PubMed: 20519402].

Gene Information

Gene Name

Protein Information

Protein Name

hemagglutinin

NCBI Protein GI

56311402

Protein pI

7.18

Protein Weight

61996.08

Protein Length

646

Protein Note

Haemagglutinin; pfam00509

Protein Sequence

>CAI29278.1 hemagglutinin [Influenza A virus (A/Hatay/2004/(H5N1))]
MEKIVLLLAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCALDGVKPLILRD
CSVAGWLLGNPMCDEFINVPEWSYIVEKANPVNDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSS
HEASLGVSSACPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQIKLYQNP
TTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKLVKKGDSTI
MKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRERRRKKRGLFG
AIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLE
RRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKC
DNECMESVRSGTYDYPQYSEEARLKREEISGVKLESIGIYQILSIYSTVASSLALAIMVAGLSLWMCSNG
SLQCRICI

Epitope Information

IEDB Linear Epitope