VIOLIN: Vaccine Investigation and Online Information Network

HA

General Information

Protegen ID

553

Sequence Strain (Species/Organism)

Influenza A virus (A/whooper swan/Mongolia/3/05(H5N1))

VO ID

VO_0011144

Taxonomy ID

344596

Other Database IDs

CDD:278910

Molecule Role

Protective antigen

Molecule Role Annotation

Chickens immunized with attenuated Salmonella strains expressing the hemagglutinin (HA1) gene from a highly pathogenic avian influenza (HPAI) H5N1 (A/whooper swan/Mongolia/3/2005) demonstrated a statistically significant increase in survival compared to control groups (Liljebjelke et al., 2010).

Related Vaccines(s)

VSV*Î”G-H5 (H5N1)

References

Liljebjelke et al., 2010: Liljebjelke KA, Petkov DI, Kapczynski DR. Mucosal vaccination with a codon-optimized hemagglutinin gene expressed by attenuated Salmonella elicits a protective immune response in chickens against highly pathogenic avian influenza. Vaccine. 2010; 28(27); 4430-4437. [PubMed: 20406663].

Gene Information

Gene Name

Protein Information

Protein Name

hemagglutinin

NCBI Protein GI

81687119

Protein pI

6.67

Protein Weight

61979.74

Protein Length

661

Protein Note

Haemagglutinin; pfam00509

Protein Sequence

>BAE48316.1 hemagglutinin [Influenza A virus (A/whooper swan/Mongolia/3/05(H5N1))]
MEKIVLLLAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCDLDGVKPLILRD
CSVAGWLLGNPMCDEFLNVPEWSYIVEKINPANDLCYPGNFNDYEELKHLLSRINHFEKIQIIPKSSWSD
HEASSGVSSACPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTRLYQNP
TTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPENAYKIVKKGDSTI
MKSELEYGNCNTKCQTPIGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQGERRRRKRGLFG
AIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLE
RRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHRC
DNECMESVRNGTYDYPQYSEEARLKREEISGVKLESIGTYQILSIYSTVASSLALAIMVAGLSLWMCSNG
SLQCRICI

Epitope Information

IEDB Linear Epitope