VIOLIN: Vaccine Investigation and Online Information Network

E

General Information

Protegen ID

554

Sequence Strain (Species/Organism)

Japanese encephalitis virus

VO ID

VO_0011145

Taxonomy ID

11072

Other Database IDs

CDD:279241
CDD:213392
CDD:213897

Molecule Role

Protective antigen

Molecule Role Annotation

Researchers constructed a recombinant pseudotype baculovirus encoding the JEV envelope (E) protein and demonstrated that it could elicit high protective immunity in mice. Intramuscular injections of BV-G-E at various doses into mice produced higher levels of JEV-specific neutralizing antibodies, IFN-gamma and better protective efficacy against a lethal challenge with JEV than that of pc-E. Furthermore, BV-G-E could elicit a higher level of cellular immunity response and provide equal protective efficacy against JEV challenge compared to inactivated vaccine (Li et al., 2009).

Related Vaccines(s)

Japanese encephalitis virus DNA vaccine encoding E protein , Japanese encephalitis virus DNA Vaccine P-JEV , Japanese encephalitis virus DNA Vaccine pCJ-3/E encoding E , Japanese encephalitis virus vaccine BV-G-E , NYVAC-JEV- prM/E/ NS1

References

Li et al., 2009: Li Y, Ye J, Cao S, Xiao S, Zhao Q, Liu X, Jin M, Chen H. Immunization with pseudotype baculovirus expressing envelope protein of Japanese encephalitis virus elicits protective immunity in mice. The journal of gene medicine. 2009; 11(1); 57-65. [PubMed: 19006097].

Gene Information

Gene Name

Protein Information

Protein Name

envelope protein

NCBI Protein GI

16445023

Protein pI

7.88

Protein Weight

49812.26

Protein Length

577

Protein Note

Flavivirus glycoprotein, central and dimerization domains; pfam00869

Protein Sequence

>AAK31640.1 envelope protein, partial [Japanese encephalitis virus]
FNCLGMGNRDFIEGASGATWVDLVLEGDSCLTIMANDKPTLDVRMINIEASQLAEVRSYCYHASVTDIST
VARCPTTGEAHNEKRADSSYVCKQGFTDRGWGNGCGLFGKGSIDTCAKFSCTSKAIGRTIQPENIKYKVG
IFVHGATTSENHGNYSAQVGASQAAKFTVTPNAPSITLKLGDYGEVTLDCEPRSGLNTEAFYVMTVGSKS
FLVHREWFHDLALPWTSPSSTAWRNRELLMEFEEAHATKQSVVALGSQEGGLHQALAGAIVVEYSSSVKL
TSGHLKCRLKMDKLALKGTTYGMCTEKFSFAKNPADTGHGTVVIELSYSGSDGPCKIPIVSVASLNDMTP
VGRLVTVNPFVATSSANSKVLVEMEPPFGDSYIVVGRGDKQINHHWHKAGSTLGKAFSTTLKGAQRLAAL
GDTAWDFGSIGGVFNSIGKAVHQVFGGAFRTLFGGMSWITQGLMGALLLWMGVNARDRSIALAFLATGGV
LVFLATNVHA

Epitope Information

IEDB Linear Epitope