VIOLIN: Vaccine Investigation and Online Information Network

PrM

General Information

Protegen ID

555

Sequence Strain (Species/Organism)

Japanese encephalitis virus

VO ID

VO_0011146

Taxonomy ID

11072

Other Database IDs

CDD:279856

Molecule Role

Protective antigen

Molecule Role Annotation

Researchers established a simple and effective method for DNA immunization against Japanese encephalitis virus (JEV) infection with plasmids encoding the viral PrM and E proteins and colloidal gold. After being inoculated twice, BALB/c mice were found to resist challenge with 100,000 times the 50% lethal dose (LD(50)) of JEV (Beijing-1 strain) even when immunized with a relatively small dose of 0.5 micro g of plasmid DNA (Zhao et al., 2003).

Related Vaccines(s)

Japanese encephalitis virus DNA vaccine encoding E protein , Japanese encephalitis virus DNA vaccine encoding PrM , NYVAC-JEV- prM/E/ NS1

References

Zhao et al., 2003: Zhao Z, Wakita T, Yasui K. Inoculation of plasmids encoding Japanese encephalitis virus PrM-E proteins with colloidal gold elicits a protective immune response in BALB/c mice. Journal of virology. 2003; 77(7); 4248-4260. [PubMed: 12634382].

Gene Information

Gene Name

PrM

Protein Information

Protein Name

PrM

NCBI Protein GI

90019439

Protein pI

4.01

Protein Weight

8654.05

Protein Length

138

Protein Note

Flavivirus polyprotein propeptide; pfam01570

Protein Sequence

>ABD84370.1 PrM, partial [Japanese encephalitis virus]
VIACVGAMKLSNFQGKLLMTINKTDIADVIVIPTSKGENRCWVRAIDVGYMCEDTITYECPKLTMGNDPE
DVDCWCDNQE

Epitope Information

IEDB Linear Epitope