VIOLIN: Vaccine Investigation and Online Information Network

F1-ATPase

General Information

Protegen ID

564

Sequence Strain (Species/Organism)

Leishmania donovani

VO ID

VO_0011154

Taxonomy ID

5661

Other Database IDs

CDD:304359
CDD:238540
CDD:278722

Molecule Role

Protective antigen

Molecule Role Annotation

Study compared the vaccine efficacy of various L. donovani antigens encapsulated in cationic liposomes in BALB/c mice against challenge infection with L. donovani. Results demonstrated that liposomal LD31 (ATP synthase alpha chain) reduced parasite burden by 74%-77% (Bhowmick and Ali, 2009).

Related Vaccines(s)

L. donovani LD31 Protein Vaccine

References

Bhowmick and Ali, 2009: Bhowmick S, Ali N. Identification of novel Leishmania donovani antigens that help define correlates of vaccine-mediated protection in visceral leishmaniasis. PloS one. 2009; 4(6); e5820. [PubMed: 19503834].

Gene Information

Gene Name

F1-ATPase

Protein Information

Protein Name

F1-ATPase beta subunit

NCBI Protein GI

722242

Protein pI

4.18

Protein Weight

20953.9

Protein Length

292

Protein Note

promastigotes of Leishmania donovani Sudan 1S maintained in liquid culture as a suspension

Protein Sequence

>AAA73465.1 F1-ATPase beta subunit, partial (mitochondrion) [Leishmania donovani]
KVALVYGQMNEPPGARAGVAESAVTMAEYFRDVEGQNVLLFIDNIFRFTQANSEVSALLGRIPAAVGYQP
TLAEDLGMLQERITSTTKGSITSVQAVYVPADDITDPAPATTFSHLDATTVLDRAVAESGIYPAVNPLEC
ASRIMDPDVIDVDHYNVAQDIVQMLTKYKELQDIIAVLGIDELSEEDKVVVDRARKVTRFLSQPFQ

Epitope Information

IEDB Linear Epitope