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Beta-tubulin

General Information
Protegen ID 565
Sequence Strain (Species/Organism) Leishmania donovani
VO ID VO_0011155
Taxonomy ID 5661
Other Database IDs CDD:276956
CDD:240228
Molecule Role Protective antigen
Molecule Role Annotation Study compared the vaccine efficacy of various L. donovani antigens encapsulated in cationic liposomes in BALB/c mice against challenge infection with L. donovani. Results demonstrated that liposomal LD51 (beta-tubulin) reduced parasite burden by 72%-75% (Bhowmick and Ali, 2009).
Related Vaccines(s) L. donovani Beta-tubulin Protein Vaccine
References
Bhowmick and Ali, 2009: Bhowmick S, Ali N. Identification of novel Leishmania donovani antigens that help define correlates of vaccine-mediated protection in visceral leishmaniasis. PloS one. 2009; 4(6); e5820. [PubMed: 19503834].
Gene Information
Gene Name Beta-tubulin
Protein Information
Protein Name beta tubulin
NCBI Protein GI 262233287
Protein pI 6.31
Protein Weight 37694.97
Protein Length 416
Protein Note The beta-tubulin family; cd02187
Protein Sequence 
>ACY38664.1 beta tubulin, partial [Leishmania donovani]
ESAGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVCRK
EAESCDCLQGFQLSHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVIPSPRVSDTVVEPYNTTLSVHQL
VENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVAAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPR
LHFFMMGFAPLTSRGSHQYPGLSVAELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLN
VQNKNSSYFIEWIPNNIKSSICDIPPKGLKMSVTFIGNNTCIQEMFRRVGEQFTGMFRRKACLHWYTGEG
MDE
Epitope Information
IEDB Linear Epitope