VIOLIN: Vaccine Investigation and Online Information Network

hsp70

General Information

Protegen ID

566

Sequence Strain (Species/Organism)

Leishmania donovani

VO ID

VO_0011156

Taxonomy ID

5661

Other Database IDs

CDD:302596
GOA:D2EAU9
InterPro: IPR001023
InterPro: IPR013126
InterPro: IPR018181
UniProtKB/TrEMBL: D2EAU9

Molecule Role

Protective antigen

Molecule Role Annotation

Study compared the vaccine efficacy of various L. donovani antigens encapsulated in cationic liposomes in BALB/c mice against challenge infection with L. donovani. Results demonstrated that liposomal LD72 (Hsp70) reduced parasite burden by 65%-67% (Bhowmick and Ali, 2009).

Related Vaccines(s)

L. donovani Hsp70 Protein Vaccine

References

Bhowmick and Ali, 2009: Bhowmick S, Ali N. Identification of novel Leishmania donovani antigens that help define correlates of vaccine-mediated protection in visceral leishmaniasis. PloS one. 2009; 4(6); e5820. [PubMed: 19503834].

Gene Information

Gene Name

hsp70

Protein Information

Protein Name

heat shock protein 70

NCBI Protein GI

281426606

Protein pI

5.03

Protein Weight

47979.15

Protein Length

532

Protein Note

Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; cl17037

Protein Sequence

>CAZ04896.1 heat shock protein 70, partial [Leishmania donovani]
DSQRQATKDAGTIAGLEVLRIINEPTAAAIAYGLDKGDDGKERNVLIFDLGGGTFDVTLLTIDGGIFEVK
ATNGDTHLGGEDFDNRLVTFFTEEFKRKNKGKNLASSHRALRRLRTACERAKRTLSSATQATIEIDALFE
NVDFQATITRARFEELCGDLFRSTIQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKEL
NKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNTTIPTKKSQIFS
TYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRN
QITITNDKGRLSKDEIERMVNDAMKYEADDRAQRDRVEAKNGLENYAYSMKNTLGDSNVSGKLDDSDKAT
LNKEIDVTLEWLSSNQEATKEEYEHKQKELESVCNPIMT

Epitope Information

IEDB Linear Epitope