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ORFF

General Information
Protegen ID 569
Sequence Strain (Species/Organism) Leishmania donovani
VO ID VO_0011159
Taxonomy ID 5661
Molecule Role Protective antigen
Molecule Role Annotation An expression plasmid encoding both p35 and p40 subunits of IL-12 when co-administered with a recombinant open-reading frame (rORFF) gene from the LD1 locus of Leishmania donovani induces significant protection with around 82% protection in both liver and spleen of BALB/c mice when challenged with L. donovani (Tewary et al., 2006).
Related Vaccines(s) L. donovani ORFF Protein Vaccine
References
Tewary et al., 2006: Tewary P, Saxena S, Madhubala R. Co-administration of IL-12 DNA with rORFF antigen confers long-term protective immunity against experimental visceral leishmaniaisis. Vaccine. 2006; 24(13); 2409-2416. [PubMed: 16413950].
Gene Information
Gene Name ORFF
Protein Information
Protein Name unknown
NCBI Protein GI 703122
Protein pI 5.32
Protein Weight 29594.74
Protein Length 334
Protein Sequence 
>AAA96728.1 unknown [Leishmania donovani]
MQSDARELNPGRADFWEHFYGQEDGRLQQKELHHRKAREIVERGSLMNHYEWFMQYPMYEAALKACLRAV
PTVLSKDGATRILHTGCGNSDFCDHVEGLLSDLNPAPSSSSRTCEVLNVDICENIVTHLALHFPSRLYAV
GDCCDLHVSSSPSMPFSSNAAWYSRDTALRLRTVLQSSVDVVFDKGTADALLSSFAGVCNPNMEAYVGEA
LKVLRPGGLLFLISINSEDVLSPYVLSAGDGLKSFQLAYADVIELCAQDLRHLRVETLGSRYSCYGYAVV
ASAVAE
Epitope Information
IEDB Linear Epitope