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HASPB1

General Information
Protegen ID 572
Sequence Strain (Species/Organism) Leishmania donovani
VO ID VO_0011162
Taxonomy ID 5661
Other Database IDs CDD:273344
Molecule Role Protective antigen
Molecule Role Annotation Study demonstrated for the first time that a recombinant stage-specific hydrophilic surface protein of Leishmania donovani, recombinant hydrophilic acylated surface protein B1 (HASPB1), is able to confer protection against experimental challenge with L. donovani in BALB/c mice (Stäger et al., 2000).
Related Vaccines(s) L. donovani HASPB1 Protein Vaccine
References
Stäger et al., 2000: Stäger S, Smith DF, Kaye PM. Immunization with a recombinant stage-regulated surface protein from Leishmania donovani induces protection against visceral leishmaniasis. Journal of immunology (Baltimore, Md. : 1950). 2000; 165(12); 7064-7071. [PubMed: 11120835].
Gene Information
Gene Name HASPB1
Protein Information
Protein Name cell surface protein B1
NCBI Protein GI 51847753
Protein pI 4.46
Protein Weight 15792.04
Protein Length 217
Protein Note K+-dependent Na+/Ca+ exchanger; TIGR00927
Protein Sequence 
>AAU10514.1 cell surface protein B1, partial [Leishmania donovani]
PKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDG
PKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDAPKEDGRTQRNDGDG
PKEDGH
Epitope Information
IEDB Linear Epitope