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MDV095

General Information
Protegen ID 575
Sequence Strain (Species/Organism) Gallid alphaherpesvirus 2
VO ID VO_0011165
Taxonomy ID 10390
Molecule Role Protective antigen
Molecule Role Annotation Recombinant fowl poxviruses (rFPVs) were constructed to express genes from serotype 1 Marek's disease virus (MDV, Gallid herpesvirus 2). rFPV/gI expressing MDV095 conferred 43% protection in maternal antibody-positive chickens when challenged with highly virulent MDV isolates (Lee et al., 2003).
Related Vaccines(s) Marek's Disease Virus Vaccine rFPV/gI
References
Lee et al., 2003: Lee LE, Witter RL, Reddy SM, Wu P, Yanagida N, Yoshida S. Protection and synergism by recombinant fowl pox vaccines expressing multiple genes from Marek's disease virus. Avian diseases. 2003; 47(3); 549-558. [PubMed: 14562881].
Gene Information
Gene Name MDV095
NCBI Gene ID 4811454
Genbank Accession AF243438
Locus Tag MD5V_095
Gene Starting Position 161182
Gene Ending Position 164094
DNA Sequence 
>NC_002229.3:161182-164094 Gallid herpesvirus 2, complete genome
GATGTATCTACTACAATTATTATTTTGGATCCGCCTCTTTCGAGGCATCTGGTCTATAGTTTATACTGGA
ACATCTGTTACGTTATCAACGGACCAATCTGCTCTTGTTGCGTTCTGCGGATTAGATAAAATGGTGAATG
TACGCGGCCAACTTTTATTCCTGGGCGACCAGACTCGGACCAGTTCTTATACAGGAACGACGGAAATCTT
GAAATGGGATGAAGAATATAAATGCTATTCCGTTCTACATGCGACATCATATATGGATTGTCCTGCTATA
GACGCCACGGTATTCAGAGGCTGTAGAGACGCTGTGGTATATGCTCAACCTCATGATAGAGTACAACCTT
TTCCCGAAAAGGGAACATTGTTGAGAATTGTCGAACCCAGAGTATCAGATACAGGCAGCTATTACATACG
TGTAGCTCTCGCTGGAAGAAATATGAGCGATATATTTAGAATGGCTGTTATTATAAGGAGTAGCAAATCT
TGGGCCTGTAATCACTCTGCTAGTTCATTTCAGGCCCATAAATGTATTCGCTATGTCGACCGTATGGCCT
TTGAAAATTATCTGATTGGACATGTAGGCAATTTGCTGGACAGTGACTCGGAATTGCATGCAATTTATAA
TATTACTCCCCAATCCATTTCCACAGATATTAATATTATAACGACTCCATTTTACGATAATTCGGGAACA
ATTTATTCACCTACGGTTTTTAATTTGTTTAATAACAATTCCCATGTCGATGCAATGAATTCGACTGGTA
TGTGGAATACCGTTTTAAAATATACCCTTCCAAGGCTTATTTACTTTTCTACGATGATTGTACTATGTAT
AATAGCATTGGCAATTTATTTGGTCTGTGAAAGGTGCCGCTCTCCCCATCGTAGGATATACATCGGTGAA
CCAAGATCTGATGAGGCCCCACTCATCACTTCTGCAGTTAACGAATCATTTCAATATGATTATAATGTAA
AGGAAACTCCTTCAGATGTTATTGAAAAGGAGTTGATGGAAAAACTGAAGAAGAAAGTCGAATTGTTGGA
AAGAGAAGAATGTGTATAGGTTTGAGAAACTATTATAGGTAGGTGGTACCTGTTAGCTTAGTATAAGGGG
AGGAGCCGTTTCTTGTTTTAAAGACACGAACACAAGGCAGTAAGTTTTATATGTGAATTTTGTGCATGTC
TGCGAGTCAGCGTCATAATGTGTGTTTTCCAAATCCTGATAATAGTGACGACGATCAAAGTAGCTGGAAC
GGCCAACATAAATCATATAGACGTTCCTGCAGGACATTCTGCTACAACGACGATCCCGCGATATCCACCA
GTTGTCGATGGGACCCTTTACACCGAGACGTGGACATGGATTCCCAATCACTGCAACGAAACGGCAACAG
GCTATGTATGTCTGGAAAGTGCTCACTGTTTTACCGATTTGATATTAGGAGTATCCTGCATGAGGTATGC
GGATGAAATCGTCTTACGAACTGATAAATTTATTGTCGATGCGGGATCCATTAAACAAATAGAATCGCTA
AGTCTGAATGGAGTTCCGAATATATTCCTATCTACGAAAGCAAGTAACAAGTTGGAGATACTAAATGCTA
GCCTACAAAATGCGGGTATCTACATTCGGTATTCTAGAAATGGGACGAGGACTGCAAAGCTGGATGTTGT
TGTGGTTGGCGTTTTGGGTCAAGCAAGGGATCGCCTACCCCAAATGTCCAGTCCTATGATCTCATCCCAC
GCCGATATCAAGTTGTCATTAAAAAACTTTAAAGCATTAGTATATCACGTGGGAGATACTATCAATGTCT
CGACGGCGGTTATACTAGGACCTTCTCCGGAGATATTCACATTGGAATTTAGGGTGTTGTTCCTCCGTTA
TAATCCAACGTGCAAGTTCGTCACGATTTATGAACCTTGTATATTTCACCCCAAAGAACCAGAGTGTATT
ACTACTGCAGAACAATCGGTATGTCATTTCGCATCCAACATTGACATTCTGCAGATAGCCGCCGCACGTT
CTGAAAATTGTAGCACAGGGTATCGTAGATGTATTTATGACACGGCTATCGATGAATCTGTGCAGGCCAG
ATTAACATTCATAGAACCAGGAATTCCTTCCTTTAAAATGAAAGATGTCCAGGTAGACGATGCTGGATTG
TATGTGGTTGTGGCTTTATACAATGGACGTCCAAGTGCATGGACTTACATTTATTTGTCAACGGTGGAAA
CATATCTTAATGTATATGAAAACTACCACAAGCCGGGATTTGGGTATAAATCATTTCTACAGAACAGTAG
TATCGTCGACGAAAATGAGGCTAGCGATTGGTCCAGCTCGTCCATTAAACGGAGAAATAATGGTACTATC
ATTTATGATATTTTACTCACATCGCTATCAATTGGGGCGATTATTATCGTCATAGTAGGGGGTGTTTGTA
TTGCCATATTAATTAGGCGTAGGAGACGACGTCGCACGAGGGGGTTATTCGATGAATATCCCAAATATAT
GACGCTACCAGGAAACGATCTGGGGGGCATGAATGTACCGTATGATAATACATGCTCTGGTAACCAAGTT
GAATATTATCAAGAAAAGTCGGCTAAAATGAAAAGAATGGGTTCGGGTTATACCGCTTGGCTAAAAAATG
ATATGCCGAAAATTAGGAAACGCTTAGATTTATACCACTGATATGTACATATTTAAACTTAATGGGATAT
AGTATATGGACGTCTATATGACGAGAGTAAATAAACTGACACTGCAAATGAAGCTGATCTATATTGTGCT
TTATATTGGGACAAACCACTCGCACAAGCTCATTCAACACATCCACTCTTGCTATTAAATTCCCCATTAT
ATAACAATACTGACATAACACTCATATTAAGGGGAGAAAATAA
Protein Information
Protein Name envelope glycoprotein I
NCBI Protein GI 125745128
Protein Accession YP_001034012
Protein pI 6.7
Protein Weight 37988.3
Protein Length 355
Protein Note envelope glycoprotein I; the Herpesviridae are non-segmented dsDNA viruses with genomes ranging from 120-230kbp; although herpes viruses vary greatly in sequence identity and homology, they all share four common elements: an envelope, a tegument which is composed of viral enzymes, a capsid of 162 capsomers, and a core composed of genomic DNA;virion envelope glycoproteins bind to cellular receptors; envelope glycoprotein E and glycoprotein I form a heterodimer that play important roles in virus cell-to-cell spread
Protein Sequence 
>YP_001034012.1 envelope glycoprotein I [Gallid alphaherpesvirus 2]
MYLLQLLFWIRLFRGIWSIVYTGTSVTLSTDQSALVAFCGLDKMVNVRGQLLFLGDQTRTSSYTGTTEIL
KWDEEYKCYSVLHATSYMDCPAIDATVFRGCRDAVVYAQPHDRVQPFPEKGTLLRIVEPRVSDTGSYYIR
VALAGRNMSDIFRMAVIIRSSKSWACNHSASSFQAHKCIRYVDRMAFENYLIGHVGNLLDSDSELHAIYN
ITPQSISTDINIITTPFYDNSGTIYSPTVFNLFNNNSHVDAMNSTGMWNTVLKYTLPRLIYFSTMIVLCI
IALAIYLVCERCRSPHRRIYIGEPRSDEAPLITSAVNESFQYDYNVKETPSDVIEKELMEKLKKKVELLE
REECV
Vaxign Prediction
Localization(Probability)
(Prob.=0)
Adhesin Probability 0.150
Trans-membrane Helices 1
Detailed Vaxign Results Vaxign Results
Epitope Information
IEDB Linear Epitope