VIOLIN: Vaccine Investigation and Online Information Network

HN

General Information

Protegen ID

582

Sequence Strain (Species/Organism)

Mumps rubulavirus

VO ID

VO_0011171

Taxonomy ID

1979165

Molecule Role

Protective antigen

Molecule Role Annotation

A novel mumps vaccine with good immunity and safety was developed by selecting an antigen (HN) component of the mumps virus. The clinical and pathological observations after challenge of vaccinated rhesus monkeys indicated further that the immune response induced by this vaccine provided complete protection from wild-type virus infection (Liang et al., 2008).

Related Vaccines(s)

Mumps HN Protein Subunit Vaccine , rvOka-HN (mumps virus)

References

Liang et al., 2008: Liang Y, Ma S, Yang Z, Liu L, Wang L, Wang J, Jiang L, Shi C, Dong C, Li Q. Immunogenicity and safety of a novel formalin-inactivated and alum-adjuvanted candidate subunit vaccine for mumps. Vaccine. 2008; 26(33); 4276-4283. [PubMed: 18597904].

Gene Information

Gene Name

NCBI Gene ID

1489765

Genbank Accession

AB040874

Locus Tag

MuVgp6

Gene Starting Position

6613

Gene Ending Position

8361

DNA Sequence

>NC_002200.1:6613-8361 Mumps virus, complete genome
GATGGAGCCCTCCAAACTCTTCACAATGTCAGACAATGCCACCTTTGCACCTGGGCCTGTTATCAATGCG
GCTGACAAGAAGACATTCCGAACCTGCTTCCGAATATTGGTACTGTCTGTACAAGCTGTTACCCTTATAT
TAGTTATTGTCACTTTAGGTGAGCTTGTGAGGATGATCAATGATCAAGGCTTGAGCAATCAGTTGTCTTC
AATTGCAGACAAGATAAGAGAGTCAGCTACTATGATTGCATCTGCTGTGGGAGTAATGAATCAAGTTATT
CACGGAGTAACGGTATCCTTACCCCTACAAATTGAGGGAAACCAAAATCAATTGTTATCCACGCTTGCCA
CAATCTGTACAGGCAAAAAACAAGTCTCAAACTGCTCTACAAACATCCCCTTAGTTAATGACCTTAGGTT
TATAAATGGGATCAATAAATTCATCATTGAAGATTATGCAACTCATGATTTCTCTATCGGCCATCCACTC
AACATGCCTAGCTTTATCCCAACTGCAACTTCACCCAATGGTTGCACAAGAATTCCATCCTTTTCTCTAG
GTAAGACACACTGGTGCTACACACATAATGTAATTAATGCCAACTGCAAGGATCATACTTCGTCCAACCA
ATATATTTCCATGGGGATACTTGTTCAGACCGCGTCAGGGTATCCTATGTTCAAAACCTTAAAGATCCAA
TATCTCAGTGATGGCCTGAATCGGAAAAGCTGCTCAATTGCAACAGTCCCTGATGGATGCGCAATGTACT
GTTATGTCTCAACTCAACTTGAAACCGACGACTATGCGGGGTCCAGCCCACCTACCCAGAAACTTACCCT
GTTATTCTATAATGATACCGTCACAGAAAGGACAATATCTCCAACTGGTCTCGAAGGGAACTGGGCCACT
TTGGTTCCAGGAGTGGGGAGTGGAATATATTTCGAGAATAAATTGATCTTTCCTGCATATGGGGGTGTCT
TGCCCAATAGTTCACTCGGAGTTAAATCAGCAAGAGAATTTTTCCGGCCTGTTAATCCATATAATCCATG
TTCAGGACCACAACAAGATTTAGATCAGCGTGCTTTGAGATCATACTTCCCAAGTTACTTCTCTAATCGA
AGAGTACAGAGTGCATTTCTTGTCTGTGCCTGGAATCAGATCCTAGTTACAAATTGCGAGCTAGTTGTCC
CCTCAAACAATCAGACACTGATGGGTGCAGAAGGAAGAGTTTTATTGATCAATAATCGACTATTATATTA
TCAGAGAAGTACCAGCTGGTGGCCGTATGAACTCCTCTATGAGATATCATTCACATTTACAAACTCTGGT
CAATCATCTGTGAATATGTCCTGGATACCTATATATTCATTCACTCGTCCTGGTTCAGGCAACTGCAGTG
GTGAAAATGTGTGCCCAACTGCTTGTGTGTCAGGGGTTTATCTTGATCCCTGGCCATTAACTCCATATAG
CCACCAATCAGGCATTAACAGAAATTTCTATTTCACAGGTGCACTATTAAATTCAAGCACAACTAGAGTA
AATCCTACCCTTTATGTCTCTGCCCTTAATAATCTTAAAGTACTAGCCCCATATGGTAATCAGGGACTGT
TTGCCTCGTACACTACAACCACCTGCTTTCAAGATACCGGTGATGCTAGTGTGTATTGTGTTTATATTAT
GGAACTAGCATCGAATATCGTTGGAGAATTCCAAATTCTACCTGTGCTAACCAGATTGACCATCACTTG

Protein Information

Protein Name

hemagglutinin-neuraminidase

NCBI Protein GI

9695422

Protein Accession

NP_054713

Protein pI

7.68

Protein Weight

59974.82

Protein Length

582

Protein Sequence

>NP_054713.1 hemagglutinin-neuraminidase [Mumps rubulavirus]
MEPSKLFTMSDNATFAPGPVINAADKKTFRTCFRILVLSVQAVTLILVIVTLGELVRMINDQGLSNQLSS
IADKIRESATMIASAVGVMNQVIHGVTVSLPLQIEGNQNQLLSTLATICTGKKQVSNCSTNIPLVNDLRF
INGINKFIIEDYATHDFSIGHPLNMPSFIPTATSPNGCTRIPSFSLGKTHWCYTHNVINANCKDHTSSNQ
YISMGILVQTASGYPMFKTLKIQYLSDGLNRKSCSIATVPDGCAMYCYVSTQLETDDYAGSSPPTQKLTL
LFYNDTVTERTISPTGLEGNWATLVPGVGSGIYFENKLIFPAYGGVLPNSSLGVKSAREFFRPVNPYNPC
SGPQQDLDQRALRSYFPSYFSNRRVQSAFLVCAWNQILVTNCELVVPSNNQTLMGAEGRVLLINNRLLYY
QRSTSWWPYELLYEISFTFTNSGQSSVNMSWIPIYSFTRPGSGNCSGENVCPTACVSGVYLDPWPLTPYS
HQSGINRNFYFTGALLNSSTTRVNPTLYVSALNNLKVLAPYGNQGLFASYTTTTCFQDTGDASVYCVYIM
ELASNIVGEFQILPVLTRLTIT

Vaxign Prediction

Localization(Probability)

(Prob.=0)

Adhesin Probability

0.577

Trans-membrane Helices

Detailed Vaxign Results

Vaxign Results

Epitope Information

IEDB Linear Epitope