VIOLIN: Vaccine Investigation and Online Information Network

MIC3

General Information

Protegen ID

587

Sequence Strain (Species/Organism)

Toxoplasma gondii ME49

VO ID

VO_0011174

Taxonomy ID

508771

Molecule Role

Protective antigen

Molecule Role Annotation

Protective experiments of DNA vaccine pcDNA3-MIC3 (pMIC3i) in Kumming mice showed that the vaccine could significantly prolong the survival time of the mice challenged by virulent RH strains of T. gondii (Xiang et al., 2009).

Related Vaccines(s)

T. gondii DNA vaccine pcDNA3-MIC3

References

Xiang et al., 2009: Xiang W, Qiong Z, Li-peng L, Kui T, Jian-wu G, Heng-ping S. The location of invasion-related protein MIC3 of Toxoplasma gondii and protective effect of its DNA vaccine in mice. Veterinary parasitology. 2009; 166(1-2); 1-7. [PubMed: 19800170].

Gene Information

Gene Name

MIC3

NCBI Gene ID

7901253

Genbank Accession

KE139555

Chromosome No

Unknown

Locus Tag

TGME49_325800

Gene Starting Position

Gene Ending Position

917

DNA Sequence

>NW_017383630.1:8-917 Toxoplasma gondii ME49 unplaced genomic scaffold asmbl.1555, whole genome shotgun sequence
CTCACGTGAGTACCCTGGTGGGGCACTCGCAGGTGTAGCCATTCTCATGCGAGGCGTCATCAATACATCT
ACCAGGGCTGCAGTTCTCCCTGAAGGCATGACATCCAGTCCTCTTGCATCCTTGTCCCCCTTCCGGGAGG
TTCACTAGAGTTTCGCCGTCGCCGCAGGTGCATGTGTAGCTGACTGAATCGACGACGATGCACGTCCCGT
TGGGTCCGCACTTCGCGTTCCCTCTTTTTGAACAAGGATCCTCGGAGCAAGTCAACCCAGTGCCGACGAA
GCCGTCTTTGCACTTGCAGTGCACACCCCCACCCGCGTCCAAGTTTTCGACGCATTCTGCGTTTTTGTCG
CACCGATGGCCCTGCTTTTCACAGCTGCAGTCTCCTCCATAGCTTTTGTCAGGATGGTAGATGAGCGAAC
TGCTGCAAAAAATCCAGTTGCTGGAGCAGAATTCTCCGCAGCCGCCGGGGCCGCACATGGTCTTGCTGCA
GCAAGCGCTCTTGGGGCAACTGGCCCCGATGAAGTACCCGTTGTCAGTGTGCAACTGACGGTTTCGACAT
GGCTTGCCTTCACTCGAGATAGCACAGAGTTGCGTCTCCTGCTTGCTGGGGGATTGCACAGACGAGTGAG
TCTCAGTCACCGCGAAAGACGGAGCAAGACTCTCAGAGACGACTTCGCGGCTCGGCACAACTTTGTCAAA
GCTGCCCAGCTGCACAGACTTCTGAATCGGCAAAGCCTCCGCTGGGGTGCACATCCACACGGCCCCACTG
AAGGTGAGCGCGTGCAACAGCGCGGACGTCCCGCCTCGCATTTTTACCAGTGTTGGACAAGGAAGTTACA
CACAGAGTAAGGCGCGCAAACGCGCTGCACTGCCCACAGAAATGCACAGAAACGCACTCTCGACGAGCTG

Protein Information

NCBI Protein GI

1085201908

Protein Accession

XP_002369833

Protein pI

6.46

Protein Weight

26732.05

Protein Length

269

Protein Sequence

>XP_002369833.2 EGF family domain-containing protein [Toxoplasma gondii ME49]
MRGGTSALLHALTFSGAVWMCTPAEALPIQKSVQLGSFDKVVPSREVVSESLAPSFAVTETHSSVQSPSK
QETQLCAISSEGKPCRNRQLHTDNGYFIGASCPKSACCSKTMCGPGGCGEFCSSNWIFCSSSLIYHPDKS
YGGDCSCEKQGHRCDKNAECVENLDAGGGVHCKCKDGFVGTGLTCSEDPCSKRGNAKCGPNGTCIVVDSV
SYTCTCGDGETLVNLPEGGQGCKRTGCHAFRENCSPGRCIDDASHENGYTCECPTRVLT

Epitope Information

IEDB Linear Epitope